Fully automated, multi-criterial planning for Volumetric Modulated Arc Therapy – An international multi-center validation for prostate cancer

Reported plan quality improvements with autoplanning of radiotherapy of the prostate and seminal vesicles are poor. A system for automated multi-criterial planning has been validated for this treatment in a large international multi-center study. The system is configured with training plans using a...

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Published in:Radiotherapy and oncology 2018-08, Vol.128 (2), p.343-348
Main Authors: Heijmen, Ben, Voet, Peter, Fransen, Dennie, Penninkhof, Joan, Milder, Maaike, Akhiat, Hafid, Bonomo, Pierluigi, Casati, Marta, Georg, Dietmar, Goldner, Gregor, Henry, Ann, Lilley, John, Lohr, Frank, Marrazzo, Livia, Pallotta, Stefania, Pellegrini, Roberto, Seppenwoolde, Yvette, Simontacchi, Gabriele, Steil, Volker, Stieler, Florian, Wilson, Stuart, Breedveld, Sebastiaan
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Language:English
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Automated multi-criterial treatment planning
Knowledge-based planning
Multi-center validation
Prostate
VMAT
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cited_by cdi_FETCH-LOGICAL-c474t-5531458d8848ce4e8fb574030fe1f2bebe5ae37f05e39422ec2f675f6c6c4b173
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creator Heijmen, Ben
Voet, Peter
Fransen, Dennie
Penninkhof, Joan
Milder, Maaike
Akhiat, Hafid
Bonomo, Pierluigi
Casati, Marta
Georg, Dietmar
Goldner, Gregor
Henry, Ann
Lilley, John
Lohr, Frank
Marrazzo, Livia
Pallotta, Stefania
Pellegrini, Roberto
Seppenwoolde, Yvette
Simontacchi, Gabriele
Steil, Volker
Stieler, Florian
Wilson, Stuart
Breedveld, Sebastiaan
description Reported plan quality improvements with autoplanning of radiotherapy of the prostate and seminal vesicles are poor. A system for automated multi-criterial planning has been validated for this treatment in a large international multi-center study. The system is configured with training plans using a mechanism that strives for quality improvements relative to those plans. Each of the four participating centers included thirty manually generated clinical Volumetric Modulated Arc Therapy prostate plans (manVMAT). Ten plans were used for autoplanning training. The other twenty were compared with an automatically generated plan (autoVMAT). Plan evaluations considered dosimetric plan parameters and blinded side-by-side plan comparisons by clinicians. With equivalent Planning Target Volume (PTV) V95%, D2%, D98%, and dose homogeneity autoVMAT was overall superior for rectum with median differences of 3.4 Gy (p 
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subjects Automated multi-criterial treatment planning
Knowledge-based planning
Multi-center validation
Prostate
VMAT
title Fully automated, multi-criterial planning for Volumetric Modulated Arc Therapy – An international multi-center validation for prostate cancer
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