The association between cardiovascular disease gene mutations and recurrent pregnancy loss in the Lebanese population

Recurrent pregnancy loss (RPL) is a problem affecting up to 5% of women of childbearing age due to many factors. Studies have shown that RPL and cardiovascular disease (CVD) may have shared risk factors. We compared the prevalence of 12 cardiovascular disease related gene mutations in patients with...

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Bibliographic Details
Published in:Molecular biology reports 2018-10, Vol.45 (5), p.911-916
Main Authors: El Achi, Hanadi, Awwad, Johnny, Abou Daya, Sarah, Halabi, Sahar, Damianos, Sandra, Mahfouz, Rami
Format: Article
Language:English
Subjects:
Abortion, Habitual - epidemiology
Abortion, Habitual - genetics
Adult
Animal Anatomy
Animal Biochemistry
Apolipoprotein E3 - genetics
Biomedical and Life Sciences
Cardiovascular disease
Cardiovascular diseases
Cardiovascular Diseases - genetics
Cross-Sectional Studies
Female
Genes
Genetic Association Studies
Genetic Predisposition to Disease
Heterozygosity
Histology
Humans
Lebanon - epidemiology
Life Sciences
Methylenetetrahydrofolate reductase
Methylenetetrahydrofolate Reductase (NADPH2) - genetics
Miscarriage
Morphology
Mutation
Mutation Rate
Original Article
Pregnancy
Prothrombin - genetics
Retrospective Studies
Risk factors
Tertiary Care Centers
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Summary:Recurrent pregnancy loss (RPL) is a problem affecting up to 5% of women of childbearing age due to many factors. Studies have shown that RPL and cardiovascular disease (CVD) may have shared risk factors. We compared the prevalence of 12 cardiovascular disease related gene mutations in patients with a history of RPL to normal controls in a major tertiary care center in Lebanon. The CVD StripAssay (ViennaLab, Austria) was used to analyze the CVD genes on 70 women with RPL history as part of the initial routine workup for recurrent miscarriage at the American University of Beirut Medical Center. The obtained results were compared with data of controls from the Lebanese population using Fisher’s exact test and Chi square analysis. Two genes of the CVD panel demonstrated a strong relationship with RPL, including, MTHFR (C677T homozygosity, A1298C homozygosity, and compound heterozygosity for C677T and A1298C) and Factor II (heterozygosity for G20210A). Moreover, a protective role of positive APO-E3 isoform was observed. This study is the first in the Lebanese population in associating RPL with a large panel of CVD related genes.
ISSN:0301-4851
1573-4978
DOI:10.1007/s11033-018-4237-1