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Influence of injectable microparticle size on cardiac progenitor cell response
Introduction: Injectable scaffolds are emerging as a promising strategy in the field of myocardial tissue engineering. Among injectable scaffolds, microparticles have been poorly investigated. The goal of this study was the development of novel gelatin/gellan microparticles that could be used as an...
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Published in: | Journal of applied biomaterials & functional materials 2018-10, Vol.16 (4), p.241-251 |
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container_title | Journal of applied biomaterials & functional materials |
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creator | Rosellini, Elisabetta Barbani, Niccoletta Frati, Caterina Madeddu, Denise Massai, Diana Morbiducci, Umberto Lazzeri, Luigi Falco, Angela Lagrasta, Costanza Audenino, Alberto Cascone, Maria Grazia Quaini, Federico |
description | Introduction:
Injectable scaffolds are emerging as a promising strategy in the field of myocardial tissue engineering. Among injectable scaffolds, microparticles have been poorly investigated. The goal of this study was the development of novel gelatin/gellan microparticles that could be used as an injectable scaffold to repair the infarcted myocardium. In particular, the effect of particle size on cardiac progenitor cell response was investigated.
Methods:
Particles were produced by a water-in-oil emulsion method. Phosphatidylcholine was used as a surfactant. Particles with different diameter ranges (125–300 µm and 350–450 µm) were fabricated using two different surfactant concentrations. Morphological, physicochemical, and functional characterizations were carried out. Cardiac progenitor cell adhesion and growth on microparticles were tested both in static and dynamic suspension culture conditions.
Results:
Morphological analysis of the produced particles showed a spherical shape and porous surface. The hydrophilicity of particle matrix and the presence of intermolecular interactions between gellan and gelatin were pointed out by the physicochemical characterization. A weight loss of 75 ± 5 % after 90 days of hydrolytic degradation was observed. Injectability through a narrow needle (26 G) and persistence of the microparticles at the injection site were preliminarily verified by ex vivo test. In vitro cell culture tests showed a preservation of rat cardiac progenitor biologic properties and indicated a preferential cell adherence to microparticles with a smaller size.
Conclusion:
Overall, the obtained results indicate that the produced gelatin/gellan microparticles could be potentially employed as injectable scaffolds for myocardial regeneration. |
doi_str_mv | 10.1177/2280800018782844 |
format | article |
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Injectable scaffolds are emerging as a promising strategy in the field of myocardial tissue engineering. Among injectable scaffolds, microparticles have been poorly investigated. The goal of this study was the development of novel gelatin/gellan microparticles that could be used as an injectable scaffold to repair the infarcted myocardium. In particular, the effect of particle size on cardiac progenitor cell response was investigated.
Methods:
Particles were produced by a water-in-oil emulsion method. Phosphatidylcholine was used as a surfactant. Particles with different diameter ranges (125–300 µm and 350–450 µm) were fabricated using two different surfactant concentrations. Morphological, physicochemical, and functional characterizations were carried out. Cardiac progenitor cell adhesion and growth on microparticles were tested both in static and dynamic suspension culture conditions.
Results:
Morphological analysis of the produced particles showed a spherical shape and porous surface. The hydrophilicity of particle matrix and the presence of intermolecular interactions between gellan and gelatin were pointed out by the physicochemical characterization. A weight loss of 75 ± 5 % after 90 days of hydrolytic degradation was observed. Injectability through a narrow needle (26 G) and persistence of the microparticles at the injection site were preliminarily verified by ex vivo test. In vitro cell culture tests showed a preservation of rat cardiac progenitor biologic properties and indicated a preferential cell adherence to microparticles with a smaller size.
Conclusion:
Overall, the obtained results indicate that the produced gelatin/gellan microparticles could be potentially employed as injectable scaffolds for myocardial regeneration.</description><identifier>ISSN: 2280-8000</identifier><identifier>EISSN: 2280-8000</identifier><identifier>DOI: 10.1177/2280800018782844</identifier><identifier>PMID: 29974809</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Animals ; Biocompatible Materials ; Cell Adhesion ; Cell adhesion & migration ; Cell culture ; Cell Proliferation ; Cell size ; Cells (biology) ; Cells, Cultured ; Emulsions ; Gelatin ; Gelatin - chemistry ; Gellan gum ; Heart ; In vitro methods and tests ; Injectability ; Lecithin ; Microparticles ; Microspheres ; Morphology ; Myocardium ; Myocardium - cytology ; Myocytes, Cardiac - cytology ; Myocytes, Cardiac - physiology ; Particle Size ; Phosphatidylcholine ; Polysaccharides, Bacterial - chemistry ; Porosity ; Preservation ; Progenitor cells ; Rats ; Regeneration ; Stem Cells - cytology ; Stem Cells - physiology ; Surfactants ; Suspension culture ; Tissue engineering ; Tissue Engineering - methods ; Tissue Scaffolds</subject><ispartof>Journal of applied biomaterials & functional materials, 2018-10, Vol.16 (4), p.241-251</ispartof><rights>The Author(s) 2018</rights><rights>The Author(s) 2018. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the associated terms available at: https://uk.sagepub.com/en-gb/eur/reusing-open-access-and-sage-choice-content</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c407t-bb44a25586ea186291778f8e82114b56a48e3cf2bb998eb6cead7cf5c8db2c033</citedby><cites>FETCH-LOGICAL-c407t-bb44a25586ea186291778f8e82114b56a48e3cf2bb998eb6cead7cf5c8db2c033</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/2280800018782844$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2313775628?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,21966,25753,27853,27924,27925,37012,37013,44590,44945,45333</link.rule.ids><linktorsrc>$$Uhttps://journals.sagepub.com/doi/full/10.1177/2280800018782844?utm_source=summon&utm_medium=discovery-provider$$EView_record_in_SAGE_Publications$$FView_record_in_$$GSAGE_Publications</linktorsrc><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29974809$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rosellini, Elisabetta</creatorcontrib><creatorcontrib>Barbani, Niccoletta</creatorcontrib><creatorcontrib>Frati, Caterina</creatorcontrib><creatorcontrib>Madeddu, Denise</creatorcontrib><creatorcontrib>Massai, Diana</creatorcontrib><creatorcontrib>Morbiducci, Umberto</creatorcontrib><creatorcontrib>Lazzeri, Luigi</creatorcontrib><creatorcontrib>Falco, Angela</creatorcontrib><creatorcontrib>Lagrasta, Costanza</creatorcontrib><creatorcontrib>Audenino, Alberto</creatorcontrib><creatorcontrib>Cascone, Maria Grazia</creatorcontrib><creatorcontrib>Quaini, Federico</creatorcontrib><title>Influence of injectable microparticle size on cardiac progenitor cell response</title><title>Journal of applied biomaterials & functional materials</title><addtitle>J Appl Biomater Funct Mater</addtitle><description>Introduction:
Injectable scaffolds are emerging as a promising strategy in the field of myocardial tissue engineering. Among injectable scaffolds, microparticles have been poorly investigated. The goal of this study was the development of novel gelatin/gellan microparticles that could be used as an injectable scaffold to repair the infarcted myocardium. In particular, the effect of particle size on cardiac progenitor cell response was investigated.
Methods:
Particles were produced by a water-in-oil emulsion method. Phosphatidylcholine was used as a surfactant. Particles with different diameter ranges (125–300 µm and 350–450 µm) were fabricated using two different surfactant concentrations. Morphological, physicochemical, and functional characterizations were carried out. Cardiac progenitor cell adhesion and growth on microparticles were tested both in static and dynamic suspension culture conditions.
Results:
Morphological analysis of the produced particles showed a spherical shape and porous surface. The hydrophilicity of particle matrix and the presence of intermolecular interactions between gellan and gelatin were pointed out by the physicochemical characterization. A weight loss of 75 ± 5 % after 90 days of hydrolytic degradation was observed. Injectability through a narrow needle (26 G) and persistence of the microparticles at the injection site were preliminarily verified by ex vivo test. In vitro cell culture tests showed a preservation of rat cardiac progenitor biologic properties and indicated a preferential cell adherence to microparticles with a smaller size.
Conclusion:
Overall, the obtained results indicate that the produced gelatin/gellan microparticles could be potentially employed as injectable scaffolds for myocardial regeneration.</description><subject>Animals</subject><subject>Biocompatible Materials</subject><subject>Cell Adhesion</subject><subject>Cell adhesion & migration</subject><subject>Cell culture</subject><subject>Cell Proliferation</subject><subject>Cell size</subject><subject>Cells (biology)</subject><subject>Cells, Cultured</subject><subject>Emulsions</subject><subject>Gelatin</subject><subject>Gelatin - chemistry</subject><subject>Gellan gum</subject><subject>Heart</subject><subject>In vitro methods and tests</subject><subject>Injectability</subject><subject>Lecithin</subject><subject>Microparticles</subject><subject>Microspheres</subject><subject>Morphology</subject><subject>Myocardium</subject><subject>Myocardium - cytology</subject><subject>Myocytes, Cardiac - cytology</subject><subject>Myocytes, Cardiac - physiology</subject><subject>Particle Size</subject><subject>Phosphatidylcholine</subject><subject>Polysaccharides, Bacterial - chemistry</subject><subject>Porosity</subject><subject>Preservation</subject><subject>Progenitor cells</subject><subject>Rats</subject><subject>Regeneration</subject><subject>Stem Cells - cytology</subject><subject>Stem Cells - physiology</subject><subject>Surfactants</subject><subject>Suspension culture</subject><subject>Tissue engineering</subject><subject>Tissue Engineering - methods</subject><subject>Tissue Scaffolds</subject><issn>2280-8000</issn><issn>2280-8000</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><recordid>eNp1kL1PwzAQxS0EohV0Z0KRWFgCtuPYzogqPipVsMAc2c6lcpU4wU4G-Otx1PKhSkw-n3737t1D6ILgG0KEuKVUYokxJlJIKhk7QvOplU694z_1DC1C2MYCS8KLPDtFM1oUgklczNHzytXNCM5A0tWJdVswg9INJK01vuuVH6yJv2A_I-ASo3xllUl6323A2aHziYGmSTyEvnMBztFJrZoAi_17ht4e7l-XT-n65XG1vFunhmExpFozpmieSw6KSE6LeI-sJUhKCNM5V0xCZmqqdVFI0NyAqoSpcyMrTQ3OsjN0vdONRt5HCEPZ2jA5UQ66MZQUcyY4xwWL6NUBuu1G76K7kmYkEyLnVEYK76h4dQge6rL3tlX-oyS4nOIuD-OOI5d74VG3UP0MfIcbgXQHBLWB363_Cn4BUE2GhQ</recordid><startdate>201810</startdate><enddate>201810</enddate><creator>Rosellini, Elisabetta</creator><creator>Barbani, Niccoletta</creator><creator>Frati, Caterina</creator><creator>Madeddu, Denise</creator><creator>Massai, Diana</creator><creator>Morbiducci, Umberto</creator><creator>Lazzeri, Luigi</creator><creator>Falco, Angela</creator><creator>Lagrasta, Costanza</creator><creator>Audenino, Alberto</creator><creator>Cascone, Maria Grazia</creator><creator>Quaini, Federico</creator><general>SAGE Publications</general><general>Sage Publications Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7RV</scope><scope>7XB</scope><scope>8BQ</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>JG9</scope><scope>KB0</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>201810</creationdate><title>Influence of injectable microparticle size on cardiac progenitor cell response</title><author>Rosellini, Elisabetta ; Barbani, Niccoletta ; Frati, Caterina ; Madeddu, Denise ; Massai, Diana ; Morbiducci, Umberto ; Lazzeri, Luigi ; Falco, Angela ; Lagrasta, Costanza ; Audenino, Alberto ; Cascone, Maria Grazia ; Quaini, Federico</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c407t-bb44a25586ea186291778f8e82114b56a48e3cf2bb998eb6cead7cf5c8db2c033</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Animals</topic><topic>Biocompatible Materials</topic><topic>Cell Adhesion</topic><topic>Cell adhesion & migration</topic><topic>Cell culture</topic><topic>Cell Proliferation</topic><topic>Cell size</topic><topic>Cells (biology)</topic><topic>Cells, Cultured</topic><topic>Emulsions</topic><topic>Gelatin</topic><topic>Gelatin - chemistry</topic><topic>Gellan gum</topic><topic>Heart</topic><topic>In vitro methods and tests</topic><topic>Injectability</topic><topic>Lecithin</topic><topic>Microparticles</topic><topic>Microspheres</topic><topic>Morphology</topic><topic>Myocardium</topic><topic>Myocardium - cytology</topic><topic>Myocytes, Cardiac - cytology</topic><topic>Myocytes, Cardiac - physiology</topic><topic>Particle Size</topic><topic>Phosphatidylcholine</topic><topic>Polysaccharides, Bacterial - chemistry</topic><topic>Porosity</topic><topic>Preservation</topic><topic>Progenitor cells</topic><topic>Rats</topic><topic>Regeneration</topic><topic>Stem Cells - cytology</topic><topic>Stem Cells - physiology</topic><topic>Surfactants</topic><topic>Suspension culture</topic><topic>Tissue engineering</topic><topic>Tissue Engineering - methods</topic><topic>Tissue Scaffolds</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rosellini, Elisabetta</creatorcontrib><creatorcontrib>Barbani, Niccoletta</creatorcontrib><creatorcontrib>Frati, Caterina</creatorcontrib><creatorcontrib>Madeddu, Denise</creatorcontrib><creatorcontrib>Massai, Diana</creatorcontrib><creatorcontrib>Morbiducci, Umberto</creatorcontrib><creatorcontrib>Lazzeri, Luigi</creatorcontrib><creatorcontrib>Falco, Angela</creatorcontrib><creatorcontrib>Lagrasta, Costanza</creatorcontrib><creatorcontrib>Audenino, Alberto</creatorcontrib><creatorcontrib>Cascone, Maria Grazia</creatorcontrib><creatorcontrib>Quaini, Federico</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>Materials Research Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of applied biomaterials & functional materials</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Rosellini, Elisabetta</au><au>Barbani, Niccoletta</au><au>Frati, Caterina</au><au>Madeddu, Denise</au><au>Massai, Diana</au><au>Morbiducci, Umberto</au><au>Lazzeri, Luigi</au><au>Falco, Angela</au><au>Lagrasta, Costanza</au><au>Audenino, Alberto</au><au>Cascone, Maria Grazia</au><au>Quaini, Federico</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Influence of injectable microparticle size on cardiac progenitor cell response</atitle><jtitle>Journal of applied biomaterials & functional materials</jtitle><addtitle>J Appl Biomater Funct Mater</addtitle><date>2018-10</date><risdate>2018</risdate><volume>16</volume><issue>4</issue><spage>241</spage><epage>251</epage><pages>241-251</pages><issn>2280-8000</issn><eissn>2280-8000</eissn><abstract>Introduction:
Injectable scaffolds are emerging as a promising strategy in the field of myocardial tissue engineering. Among injectable scaffolds, microparticles have been poorly investigated. The goal of this study was the development of novel gelatin/gellan microparticles that could be used as an injectable scaffold to repair the infarcted myocardium. In particular, the effect of particle size on cardiac progenitor cell response was investigated.
Methods:
Particles were produced by a water-in-oil emulsion method. Phosphatidylcholine was used as a surfactant. Particles with different diameter ranges (125–300 µm and 350–450 µm) were fabricated using two different surfactant concentrations. Morphological, physicochemical, and functional characterizations were carried out. Cardiac progenitor cell adhesion and growth on microparticles were tested both in static and dynamic suspension culture conditions.
Results:
Morphological analysis of the produced particles showed a spherical shape and porous surface. The hydrophilicity of particle matrix and the presence of intermolecular interactions between gellan and gelatin were pointed out by the physicochemical characterization. A weight loss of 75 ± 5 % after 90 days of hydrolytic degradation was observed. Injectability through a narrow needle (26 G) and persistence of the microparticles at the injection site were preliminarily verified by ex vivo test. In vitro cell culture tests showed a preservation of rat cardiac progenitor biologic properties and indicated a preferential cell adherence to microparticles with a smaller size.
Conclusion:
Overall, the obtained results indicate that the produced gelatin/gellan microparticles could be potentially employed as injectable scaffolds for myocardial regeneration.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>29974809</pmid><doi>10.1177/2280800018782844</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Animals Biocompatible Materials Cell Adhesion Cell adhesion & migration Cell culture Cell Proliferation Cell size Cells (biology) Cells, Cultured Emulsions Gelatin Gelatin - chemistry Gellan gum Heart In vitro methods and tests Injectability Lecithin Microparticles Microspheres Morphology Myocardium Myocardium - cytology Myocytes, Cardiac - cytology Myocytes, Cardiac - physiology Particle Size Phosphatidylcholine Polysaccharides, Bacterial - chemistry Porosity Preservation Progenitor cells Rats Regeneration Stem Cells - cytology Stem Cells - physiology Surfactants Suspension culture Tissue engineering Tissue Engineering - methods Tissue Scaffolds |
title | Influence of injectable microparticle size on cardiac progenitor cell response |
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