Isolation, NMR spectroscopy, and conformational analysis of the antibiotic ina 2770 (cineromycin B) produced by Streptomyces strain

The antibiotic INA 2770 active against methicillin-resistant staphylococcus aureus (MRSA) was biotechnologically produced and isolated. This antibiotic is identical to cineromycin B. The characteristic features of the super(1)H and super(13)C NMR spectra of this compound were studied for the first t...

Full description

Saved in:
Bibliographic Details
Published in:Russian chemical bulletin 2007-04, Vol.56 (4), p.815-818
Main Authors: Terekhova, L. P., Galatenko, O. A., Kulyaeva, V. V., Malkina, N. D., Boikova, Yu. V., Katrukha, G. S., Shashkov, A. S., Gerbst, A. G., Nifantiev, N. E.
Format: Article
Language:English
Subjects:
Staphylococcus aureus
Streptomyces
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The antibiotic INA 2770 active against methicillin-resistant staphylococcus aureus (MRSA) was biotechnologically produced and isolated. This antibiotic is identical to cineromycin B. The characteristic features of the super(1)H and super(13)C NMR spectra of this compound were studied for the first time, and the conformational analysis was carried out by computational methods (molecular mechanics (MM3) force field) and using nuclear Overhauser effect experiments.
ISSN:1066-5285
1573-9171
DOI:10.1007/s11172-007-0121-1