Sulfur mustard-induced neutropenia: treatment with granulocyte colony-stimulating factor

Although best known as a blistering agent, sulfur mustard (HD) can also induce neutropenia in exposed individuals, increasing their susceptibility to infection. Granulocyte colony-stimulating factor (G-CSF) and pegylated G-CSF (peg-G-CSF) have been approved by the U.S. Food and Drug Administration a...

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Bibliographic Details
Published in:Military medicine 2006-05, Vol.171 (5), p.448-453
Main Authors: Anderson, Dana R, Holmes, Wesley W, Lee, Robyn B, Dalal, Stephen J, Hurst, Charles G, Maliner, Beverly I, Newmark, Jonathan, Smith, William J
Format: Article
Language:English
Subjects:
Animals
Antibiotics
Blood
Bone marrow
Chemotherapy
Drug dosages
FDA approval
Granulocyte Colony-Stimulating Factor - administration & dosage
Granulocyte Colony-Stimulating Factor - therapeutic use
Granulocytes
Growth factors
Haplorhini
Hematology
Infections
Ketamine
Laboratory animals
Leukocytes
Lymphatic system
Lymphocytes
Male
Mustard Gas - adverse effects
Neutropenia
Neutropenia - chemically induced
Neutrophils
Nitrogen
Sulfur
Toxicity
United States
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Summary:Although best known as a blistering agent, sulfur mustard (HD) can also induce neutropenia in exposed individuals, increasing their susceptibility to infection. Granulocyte colony-stimulating factor (G-CSF) and pegylated G-CSF (peg-G-CSF) have been approved by the U.S. Food and Drug Administration as hematopoietic growth factors to treat chemotherapy-induced neutropenia. The goal of this study was to determine the effectiveness of G-CSF and peg-G-CSF in ameliorating HD-induced neutropenia. African green monkeys (Chlorocebus aethiops) were challenged with HD and, at 1, 3, 5, or 7 days after exposure, G-CSF therapy (10 microg/kg per day for 21 days) was initiated. Peg-G-CSF (300 microg/kg, single treatment) was similarly tested, with treatment given at 3 days after exposure. Untreated HD-exposed animals recovered from neutropenia 28 days after exposure, whereas G-CSF- or peg-G-CSF-treated animals recovered 8 to 19 days after exposure (p < 0.05). These results indicate that G-CSF or peg-G-CSF may provide Food and Drug Administration-approved treatments that will reduce the duration of HD-induced neutropenia.
ISSN:0026-4075
1930-613X
DOI:10.7205/MILMED.171.5.448