Quantitative Study of Leydig Cell Populations in Mice Exposed to Low Doses of Cadmium

Leydig cell morphological changes were evaluated using morphometric and stereological methods in male mice exposed to low doses of cadmium. A possible reversibility of the changes after cadmium withdrawal was also considered. Nuclear morphological parameters and stereological densities of the Leydig...

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Bibliographic Details
Published in:Bulletin of environmental contamination and toxicology 2009-06, Vol.82 (6), p.756-760
Main Authors: Blanco, A., Moyano, M. R., Molina, A. M., Blanco, C., Flores-Acuña, R., García-Flores, J. R., Espada, M., Monterde, J. G.
Format: Article
Language:English
Subjects:
Animals
Aquatic Pollution
Cadmium
Cadmium - analysis
Cadmium - toxicity
Cell Nucleus - drug effects
Cell Nucleus - ultrastructure
Earth and Environmental Science
Ecotoxicology
Environment
Environmental Chemistry
Environmental Health
Hyperplasia
Leydig Cells - drug effects
Leydig Cells - pathology
Leydig Cells - ultrastructure
Male
Mice
Pollution
Quantitative research
Rodents
Soil Science & Conservation
Toxicity Tests, Chronic
Toxicology
Waste Water Technology
Water Management
Water Pollution Control
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Summary:Leydig cell morphological changes were evaluated using morphometric and stereological methods in male mice exposed to low doses of cadmium. A possible reversibility of the changes after cadmium withdrawal was also considered. Nuclear morphological parameters and stereological densities of the Leydig cell population were lower in the cadmium-exposed groups than in the control. The withdrawal of cadmium did not lead to any significant recovery of the morphological parameters. Nevertheless, numerical density increased significantly in the withdrawn groups, suggesting that the hyperplasia of interstitial cells could try to relieve morphological damage after cadmium withdrawal.
ISSN:0007-4861
1432-0800
DOI:10.1007/s00128-009-9700-1