Antifungal agent and other constituents from Cynanchum otophyllum

Seven constituents were isolated from the ethyl acetate extract of the rhizome of Cynanchum otophyllum Schneid (Asclepiadaceae). Their structures were determined as 1-(4-methoxy-3-(6-methoxy-3-acetylphenylperoxy)phenyl)ethanone (1), 1-(3-hydroxy-7-acetylnaphthalen-2-yl)ethanone (2), 1-(3,4-dihydroxy...

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Bibliographic Details
Published in:Natural product research 2007-03, Vol.21 (3), p.203-210
Main Authors: Zhao, Yi-Bin, Shen, Yue-Mao, He, Hong-Ping, Mu, Quan-Zhang, Hao, Xiao-Jiang
Format: Article
Language:English
Subjects:
Acetates
Antifungal agent
Antifungal Agents - isolation & purification
Antifungal Agents - pharmacology
Asclepiadaceae
Candida albicans - drug effects
Candidiasis - microbiology
Cynanchum - chemistry
Cynanchum otophyllum
Magnetic Resonance Spectroscopy
Microbial Sensitivity Tests
Naphthalenes - isolation & purification
Naphthalenes - pharmacology
Peroxide
Peroxides - isolation & purification
Peroxides - pharmacology
Plant Roots - chemistry
Solvents
Spectrometry, Mass, Fast Atom Bombardment
Spectrophotometry, Infrared
Spectrophotometry, Ultraviolet
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Summary:Seven constituents were isolated from the ethyl acetate extract of the rhizome of Cynanchum otophyllum Schneid (Asclepiadaceae). Their structures were determined as 1-(4-methoxy-3-(6-methoxy-3-acetylphenylperoxy)phenyl)ethanone (1), 1-(3-hydroxy-7-acetylnaphthalen-2-yl)ethanone (2), 1-(3,4-dihydroxyphenyl)ethanone (3), 1-(2,4-dihydroxyphenyl)ethanone (4), 1-(3-(3,6-dihydroxy-2-methylbenzoyl)-2,4-dihydroxyphenyl)ethanone (beishouwubenzophenone) (5), N,N-dimethylethanamine (6), and 2-oxo-2-phenylacetic acid (7), respectively, by spectral methods. Among them, 1 and 2 were new compounds; 1 had antifungal activity.
ISSN:1478-6419
1478-6427
DOI:10.1080/14786410601130364