PTEN expression in renal cell carcinoma and oncocytoma and prognosis

Deletion or inactivation of the tumour suppressor gene PTEN (phosphatase and tensin homologue deleted from chromosome 10) contributes to tumorigenesis in a variety of human carcinomas. The present study evaluated PTEN expression in renal cell carcinomas and oncocytomas. A tissue microarray from 493...

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Bibliographic Details
Published in:Pathology 2007-10, Vol.39 (5), p.482-485
Main Authors: Hager, Martina, Haufe, Heike, Kemmerling, Ralf, Mikuz, Gregor, Kolbitsch, Christian, Moser, Patrizia L.
Format: Article
Language:English
Subjects:
Adenoma, Oxyphilic - metabolism
Aged
Biomarkers, Tumor - analysis
carcinogenesis
Carcinoma, Renal Cell - metabolism
Carcinoma, Renal Cell - mortality
Carcinoma, Renal Cell - pathology
cytoplasmic
Female
Humans
Immunohistochemistry
Kaplan-Meier Estimate
Kidney Neoplasms - metabolism
Kidney Neoplasms - mortality
Kidney Neoplasms - pathology
Male
membranous
Middle Aged
Neoplasm Staging
nuclear
oncocytoma
Prognosis
PTEN expression
PTEN Phosphohydrolase - biosynthesis
Renal cell carcinoma
survival
Tissue Array Analysis
tissue microarray
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Summary:Deletion or inactivation of the tumour suppressor gene PTEN (phosphatase and tensin homologue deleted from chromosome 10) contributes to tumorigenesis in a variety of human carcinomas. The present study evaluated PTEN expression in renal cell carcinomas and oncocytomas. A tissue microarray from 493 specimens including renal cell carcinomas (n=440), oncocytomas (n=21) and tumour-negative renal tissue (n=32) from patients (n=461) was incubated with an anti-PTEN antibody for subsequent analysis of PTEN expression. Furthermore, the effect of PTEN expression on the survival of renal carcinoma patients was evaluated. Renal cell carcinomas, and even more pronouncedly oncocytomas, expressed PTEN predominantly in the cytoplasm. In contrast to oncocytomas, PTEN expression was typically decreased in renal cell carcinoma subtypes. PTEN expression in sarcomatoid renal cell carcinomas was comparable to that in non-sarcomatoid subtypes. The PTEN expression pattern had no significant influence on prognosis. Renal tumours (renal cell carcinomas and oncocytomas) express PTEN protein predominantly in the cytoplasm. A reduction in PTEN expression appears to be an early step in renal cell carcinogenesis. However, the PTEN expression pattern of renal cell carcinomas apparently is not prognostic for patient survival.
ISSN:0031-3025
1465-3931
DOI:10.1080/00313020701570012