Loading…
PTEN expression in renal cell carcinoma and oncocytoma and prognosis
Deletion or inactivation of the tumour suppressor gene PTEN (phosphatase and tensin homologue deleted from chromosome 10) contributes to tumorigenesis in a variety of human carcinomas. The present study evaluated PTEN expression in renal cell carcinomas and oncocytomas. A tissue microarray from 493...
Saved in:
| Published in: | Pathology 2007-10, Vol.39 (5), p.482-485 |
|---|---|
| Main Authors: | , , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c434t-98221a4f062bb2121d905a066afbbc594b1c130247fe9668b7d53b8a27176b823 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c434t-98221a4f062bb2121d905a066afbbc594b1c130247fe9668b7d53b8a27176b823 |
| container_end_page | 485 |
| container_issue | 5 |
| container_start_page | 482 |
| container_title | Pathology |
| container_volume | 39 |
| creator | Hager, Martina Haufe, Heike Kemmerling, Ralf Mikuz, Gregor Kolbitsch, Christian Moser, Patrizia L. |
| description | Deletion or inactivation of the tumour suppressor gene PTEN (phosphatase and tensin homologue deleted from chromosome 10) contributes to tumorigenesis in a variety of human carcinomas. The present study evaluated PTEN expression in renal cell carcinomas and oncocytomas.
A tissue microarray from 493 specimens including renal cell carcinomas (n=440), oncocytomas (n=21) and tumour-negative renal tissue (n=32) from patients (n=461) was incubated with an anti-PTEN antibody for subsequent analysis of PTEN expression. Furthermore, the effect of PTEN expression on the survival of renal carcinoma patients was evaluated.
Renal cell carcinomas, and even more pronouncedly oncocytomas, expressed PTEN predominantly in the cytoplasm. In contrast to oncocytomas, PTEN expression was typically decreased in renal cell carcinoma subtypes. PTEN expression in sarcomatoid renal cell carcinomas was comparable to that in non-sarcomatoid subtypes. The PTEN expression pattern had no significant influence on prognosis.
Renal tumours (renal cell carcinomas and oncocytomas) express PTEN protein predominantly in the cytoplasm. A reduction in PTEN expression appears to be an early step in renal cell carcinogenesis. However, the PTEN expression pattern of renal cell carcinomas apparently is not prognostic for patient survival. |
| doi_str_mv | 10.1080/00313020701570012 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_20656477</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0031302516337400</els_id><sourcerecordid>20656477</sourcerecordid><originalsourceid>FETCH-LOGICAL-c434t-98221a4f062bb2121d905a066afbbc594b1c130247fe9668b7d53b8a27176b823</originalsourceid><addsrcrecordid>eNp9kE1PxCAURYnR6PjxA9yYrtxVH7QFGlfG78SoC10ToK-KmcIIHeP8e5nMGBcmbiCEc--DQ8ghhRMKEk4BKloBAwG0EQCUbZAJrXlTVm1FN8lkeV9moNkhuym9A0AtpdwmO1RIyaEVE3L59Hz1UODXLGJKLvjC-SKi19PC4jQvOlrnw6AL7bsieBvsYvw5zmJ49SG5tE-2ej1NeLDe98jL9dXzxW15_3hzd3F-X9q6qseylYxRXffAmTGMMtq10GjgXPfG2KatDbXL_9Six5ZzaUTXVEZqJqjgRrJqjxyvevPkjzmmUQ0uLd-pPYZ5Ugx4w2shMkhXoI0hpYi9mkU36LhQFNRSnfqjLmeO1uVzM2D3m1i7ysDZCnC-D3HQb6in41s2hOo9zGN2lv6tX6cxC_p0GFWyDr3FzkW0o-qC-yf9DYwQjAw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>20656477</pqid></control><display><type>article</type><title>PTEN expression in renal cell carcinoma and oncocytoma and prognosis</title><source>ScienceDirect Freedom Collection</source><creator>Hager, Martina ; Haufe, Heike ; Kemmerling, Ralf ; Mikuz, Gregor ; Kolbitsch, Christian ; Moser, Patrizia L.</creator><creatorcontrib>Hager, Martina ; Haufe, Heike ; Kemmerling, Ralf ; Mikuz, Gregor ; Kolbitsch, Christian ; Moser, Patrizia L.</creatorcontrib><description>Deletion or inactivation of the tumour suppressor gene PTEN (phosphatase and tensin homologue deleted from chromosome 10) contributes to tumorigenesis in a variety of human carcinomas. The present study evaluated PTEN expression in renal cell carcinomas and oncocytomas.
A tissue microarray from 493 specimens including renal cell carcinomas (n=440), oncocytomas (n=21) and tumour-negative renal tissue (n=32) from patients (n=461) was incubated with an anti-PTEN antibody for subsequent analysis of PTEN expression. Furthermore, the effect of PTEN expression on the survival of renal carcinoma patients was evaluated.
Renal cell carcinomas, and even more pronouncedly oncocytomas, expressed PTEN predominantly in the cytoplasm. In contrast to oncocytomas, PTEN expression was typically decreased in renal cell carcinoma subtypes. PTEN expression in sarcomatoid renal cell carcinomas was comparable to that in non-sarcomatoid subtypes. The PTEN expression pattern had no significant influence on prognosis.
Renal tumours (renal cell carcinomas and oncocytomas) express PTEN protein predominantly in the cytoplasm. A reduction in PTEN expression appears to be an early step in renal cell carcinogenesis. However, the PTEN expression pattern of renal cell carcinomas apparently is not prognostic for patient survival.</description><identifier>ISSN: 0031-3025</identifier><identifier>EISSN: 1465-3931</identifier><identifier>DOI: 10.1080/00313020701570012</identifier><identifier>PMID: 17886097</identifier><language>eng</language><publisher>England: Elsevier B.V</publisher><subject>Adenoma, Oxyphilic - metabolism ; Aged ; Biomarkers, Tumor - analysis ; carcinogenesis ; Carcinoma, Renal Cell - metabolism ; Carcinoma, Renal Cell - mortality ; Carcinoma, Renal Cell - pathology ; cytoplasmic ; Female ; Humans ; Immunohistochemistry ; Kaplan-Meier Estimate ; Kidney Neoplasms - metabolism ; Kidney Neoplasms - mortality ; Kidney Neoplasms - pathology ; Male ; membranous ; Middle Aged ; Neoplasm Staging ; nuclear ; oncocytoma ; Prognosis ; PTEN expression ; PTEN Phosphohydrolase - biosynthesis ; Renal cell carcinoma ; survival ; Tissue Array Analysis ; tissue microarray</subject><ispartof>Pathology, 2007-10, Vol.39 (5), p.482-485</ispartof><rights>2007 Royal College of Pathologists of Australasia</rights><rights>2007 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 2007</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c434t-98221a4f062bb2121d905a066afbbc594b1c130247fe9668b7d53b8a27176b823</citedby><cites>FETCH-LOGICAL-c434t-98221a4f062bb2121d905a066afbbc594b1c130247fe9668b7d53b8a27176b823</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17886097$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hager, Martina</creatorcontrib><creatorcontrib>Haufe, Heike</creatorcontrib><creatorcontrib>Kemmerling, Ralf</creatorcontrib><creatorcontrib>Mikuz, Gregor</creatorcontrib><creatorcontrib>Kolbitsch, Christian</creatorcontrib><creatorcontrib>Moser, Patrizia L.</creatorcontrib><title>PTEN expression in renal cell carcinoma and oncocytoma and prognosis</title><title>Pathology</title><addtitle>Pathology</addtitle><description>Deletion or inactivation of the tumour suppressor gene PTEN (phosphatase and tensin homologue deleted from chromosome 10) contributes to tumorigenesis in a variety of human carcinomas. The present study evaluated PTEN expression in renal cell carcinomas and oncocytomas.
A tissue microarray from 493 specimens including renal cell carcinomas (n=440), oncocytomas (n=21) and tumour-negative renal tissue (n=32) from patients (n=461) was incubated with an anti-PTEN antibody for subsequent analysis of PTEN expression. Furthermore, the effect of PTEN expression on the survival of renal carcinoma patients was evaluated.
Renal cell carcinomas, and even more pronouncedly oncocytomas, expressed PTEN predominantly in the cytoplasm. In contrast to oncocytomas, PTEN expression was typically decreased in renal cell carcinoma subtypes. PTEN expression in sarcomatoid renal cell carcinomas was comparable to that in non-sarcomatoid subtypes. The PTEN expression pattern had no significant influence on prognosis.
Renal tumours (renal cell carcinomas and oncocytomas) express PTEN protein predominantly in the cytoplasm. A reduction in PTEN expression appears to be an early step in renal cell carcinogenesis. However, the PTEN expression pattern of renal cell carcinomas apparently is not prognostic for patient survival.</description><subject>Adenoma, Oxyphilic - metabolism</subject><subject>Aged</subject><subject>Biomarkers, Tumor - analysis</subject><subject>carcinogenesis</subject><subject>Carcinoma, Renal Cell - metabolism</subject><subject>Carcinoma, Renal Cell - mortality</subject><subject>Carcinoma, Renal Cell - pathology</subject><subject>cytoplasmic</subject><subject>Female</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Kaplan-Meier Estimate</subject><subject>Kidney Neoplasms - metabolism</subject><subject>Kidney Neoplasms - mortality</subject><subject>Kidney Neoplasms - pathology</subject><subject>Male</subject><subject>membranous</subject><subject>Middle Aged</subject><subject>Neoplasm Staging</subject><subject>nuclear</subject><subject>oncocytoma</subject><subject>Prognosis</subject><subject>PTEN expression</subject><subject>PTEN Phosphohydrolase - biosynthesis</subject><subject>Renal cell carcinoma</subject><subject>survival</subject><subject>Tissue Array Analysis</subject><subject>tissue microarray</subject><issn>0031-3025</issn><issn>1465-3931</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><recordid>eNp9kE1PxCAURYnR6PjxA9yYrtxVH7QFGlfG78SoC10ToK-KmcIIHeP8e5nMGBcmbiCEc--DQ8ghhRMKEk4BKloBAwG0EQCUbZAJrXlTVm1FN8lkeV9moNkhuym9A0AtpdwmO1RIyaEVE3L59Hz1UODXLGJKLvjC-SKi19PC4jQvOlrnw6AL7bsieBvsYvw5zmJ49SG5tE-2ej1NeLDe98jL9dXzxW15_3hzd3F-X9q6qseylYxRXffAmTGMMtq10GjgXPfG2KatDbXL_9Six5ZzaUTXVEZqJqjgRrJqjxyvevPkjzmmUQ0uLd-pPYZ5Ugx4w2shMkhXoI0hpYi9mkU36LhQFNRSnfqjLmeO1uVzM2D3m1i7ysDZCnC-D3HQb6in41s2hOo9zGN2lv6tX6cxC_p0GFWyDr3FzkW0o-qC-yf9DYwQjAw</recordid><startdate>200710</startdate><enddate>200710</enddate><creator>Hager, Martina</creator><creator>Haufe, Heike</creator><creator>Kemmerling, Ralf</creator><creator>Mikuz, Gregor</creator><creator>Kolbitsch, Christian</creator><creator>Moser, Patrizia L.</creator><general>Elsevier B.V</general><general>Informa UK Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope></search><sort><creationdate>200710</creationdate><title>PTEN expression in renal cell carcinoma and oncocytoma and prognosis</title><author>Hager, Martina ; Haufe, Heike ; Kemmerling, Ralf ; Mikuz, Gregor ; Kolbitsch, Christian ; Moser, Patrizia L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c434t-98221a4f062bb2121d905a066afbbc594b1c130247fe9668b7d53b8a27176b823</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adenoma, Oxyphilic - metabolism</topic><topic>Aged</topic><topic>Biomarkers, Tumor - analysis</topic><topic>carcinogenesis</topic><topic>Carcinoma, Renal Cell - metabolism</topic><topic>Carcinoma, Renal Cell - mortality</topic><topic>Carcinoma, Renal Cell - pathology</topic><topic>cytoplasmic</topic><topic>Female</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Kaplan-Meier Estimate</topic><topic>Kidney Neoplasms - metabolism</topic><topic>Kidney Neoplasms - mortality</topic><topic>Kidney Neoplasms - pathology</topic><topic>Male</topic><topic>membranous</topic><topic>Middle Aged</topic><topic>Neoplasm Staging</topic><topic>nuclear</topic><topic>oncocytoma</topic><topic>Prognosis</topic><topic>PTEN expression</topic><topic>PTEN Phosphohydrolase - biosynthesis</topic><topic>Renal cell carcinoma</topic><topic>survival</topic><topic>Tissue Array Analysis</topic><topic>tissue microarray</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hager, Martina</creatorcontrib><creatorcontrib>Haufe, Heike</creatorcontrib><creatorcontrib>Kemmerling, Ralf</creatorcontrib><creatorcontrib>Mikuz, Gregor</creatorcontrib><creatorcontrib>Kolbitsch, Christian</creatorcontrib><creatorcontrib>Moser, Patrizia L.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><jtitle>Pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hager, Martina</au><au>Haufe, Heike</au><au>Kemmerling, Ralf</au><au>Mikuz, Gregor</au><au>Kolbitsch, Christian</au><au>Moser, Patrizia L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>PTEN expression in renal cell carcinoma and oncocytoma and prognosis</atitle><jtitle>Pathology</jtitle><addtitle>Pathology</addtitle><date>2007-10</date><risdate>2007</risdate><volume>39</volume><issue>5</issue><spage>482</spage><epage>485</epage><pages>482-485</pages><issn>0031-3025</issn><eissn>1465-3931</eissn><abstract>Deletion or inactivation of the tumour suppressor gene PTEN (phosphatase and tensin homologue deleted from chromosome 10) contributes to tumorigenesis in a variety of human carcinomas. The present study evaluated PTEN expression in renal cell carcinomas and oncocytomas.
A tissue microarray from 493 specimens including renal cell carcinomas (n=440), oncocytomas (n=21) and tumour-negative renal tissue (n=32) from patients (n=461) was incubated with an anti-PTEN antibody for subsequent analysis of PTEN expression. Furthermore, the effect of PTEN expression on the survival of renal carcinoma patients was evaluated.
Renal cell carcinomas, and even more pronouncedly oncocytomas, expressed PTEN predominantly in the cytoplasm. In contrast to oncocytomas, PTEN expression was typically decreased in renal cell carcinoma subtypes. PTEN expression in sarcomatoid renal cell carcinomas was comparable to that in non-sarcomatoid subtypes. The PTEN expression pattern had no significant influence on prognosis.
Renal tumours (renal cell carcinomas and oncocytomas) express PTEN protein predominantly in the cytoplasm. A reduction in PTEN expression appears to be an early step in renal cell carcinogenesis. However, the PTEN expression pattern of renal cell carcinomas apparently is not prognostic for patient survival.</abstract><cop>England</cop><pub>Elsevier B.V</pub><pmid>17886097</pmid><doi>10.1080/00313020701570012</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0031-3025 |
| ispartof | Pathology, 2007-10, Vol.39 (5), p.482-485 |
| issn | 0031-3025 1465-3931 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_20656477 |
| source | ScienceDirect Freedom Collection |
| subjects | Adenoma, Oxyphilic - metabolism Aged Biomarkers, Tumor - analysis carcinogenesis Carcinoma, Renal Cell - metabolism Carcinoma, Renal Cell - mortality Carcinoma, Renal Cell - pathology cytoplasmic Female Humans Immunohistochemistry Kaplan-Meier Estimate Kidney Neoplasms - metabolism Kidney Neoplasms - mortality Kidney Neoplasms - pathology Male membranous Middle Aged Neoplasm Staging nuclear oncocytoma Prognosis PTEN expression PTEN Phosphohydrolase - biosynthesis Renal cell carcinoma survival Tissue Array Analysis tissue microarray |
| title | PTEN expression in renal cell carcinoma and oncocytoma and prognosis |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-27T11%3A58%3A16IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=PTEN%20expression%20in%20renal%20cell%20carcinoma%20and%20oncocytoma%20and%20prognosis&rft.jtitle=Pathology&rft.au=Hager,%20Martina&rft.date=2007-10&rft.volume=39&rft.issue=5&rft.spage=482&rft.epage=485&rft.pages=482-485&rft.issn=0031-3025&rft.eissn=1465-3931&rft_id=info:doi/10.1080/00313020701570012&rft_dat=%3Cproquest_cross%3E20656477%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c434t-98221a4f062bb2121d905a066afbbc594b1c130247fe9668b7d53b8a27176b823%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=20656477&rft_id=info:pmid/17886097&rfr_iscdi=true |