FcγRIIa: A New Cardiovascular Risk Marker

Platelet expression of FcγRIIa reflects megakaryocyte production that is increased by interferon gamma (3). [...]platelet expression of FcγRIIa would be expected to change as a reflection of systemic inflammation and would be less likely to exhibit the substantial intraindividual variability that ha...

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Bibliographic Details
Published in:Journal of the American College of Cardiology 2018-07, Vol.72 (2), p.237-238
Main Authors: Schneider, David J., McMahon, Sean R., Chava, Sreedivya, Taatjes-Sommer, Heidi S., Meagher, Sean, Ehle, Gregory L., Brummel-Ziedins, Kathleen E.
Format: Article
Language:English
Subjects:
Cardiology
Diabetes
Patients
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Summary:Platelet expression of FcγRIIa reflects megakaryocyte production that is increased by interferon gamma (3). [...]platelet expression of FcγRIIa would be expected to change as a reflection of systemic inflammation and would be less likely to exhibit the substantial intraindividual variability that has been observed with currently available tests of platelet function (1). [...]platelet FcγRIIa expression provides a tangible link between systemic inflammation and increased platelet reactivity. In summary, we found that increased platelet FcγRIIa expression identifies patients at greater risk of CVE. Because FcγRIIa augments platelet reactivity (2), we propose that platelet FcγRIIa expression is a new marker of increased platelet reactivity capable of identifying patients at increased risk of CVE and that platelet FcγRIIa expression is likely to be a more consistent marker of increased platelet reactivity over time.
ISSN:0735-1097
1558-3597
DOI:10.1016/j.jacc.2018.04.046