FcγRIIa: A New Cardiovascular Risk Marker

Platelet expression of FcγRIIa reflects megakaryocyte production that is increased by interferon gamma (3). [...]platelet expression of FcγRIIa would be expected to change as a reflection of systemic inflammation and would be less likely to exhibit the substantial intraindividual variability that ha...

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Published in:Journal of the American College of Cardiology 2018-07, Vol.72 (2), p.237-238
Main Authors: Schneider, David J., McMahon, Sean R., Chava, Sreedivya, Taatjes-Sommer, Heidi S., Meagher, Sean, Ehle, Gregory L., Brummel-Ziedins, Kathleen E.
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Language:English
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Cardiology
Diabetes
Patients
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container_end_page 238
container_issue 2
container_start_page 237
container_title Journal of the American College of Cardiology
container_volume 72
creator Schneider, David J.
McMahon, Sean R.
Chava, Sreedivya
Taatjes-Sommer, Heidi S.
Meagher, Sean
Ehle, Gregory L.
Brummel-Ziedins, Kathleen E.
description Platelet expression of FcγRIIa reflects megakaryocyte production that is increased by interferon gamma (3). [...]platelet expression of FcγRIIa would be expected to change as a reflection of systemic inflammation and would be less likely to exhibit the substantial intraindividual variability that has been observed with currently available tests of platelet function (1). [...]platelet FcγRIIa expression provides a tangible link between systemic inflammation and increased platelet reactivity. In summary, we found that increased platelet FcγRIIa expression identifies patients at greater risk of CVE. Because FcγRIIa augments platelet reactivity (2), we propose that platelet FcγRIIa expression is a new marker of increased platelet reactivity capable of identifying patients at increased risk of CVE and that platelet FcγRIIa expression is likely to be a more consistent marker of increased platelet reactivity over time.
doi_str_mv 10.1016/j.jacc.2018.04.046
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subjects Cardiology
Diabetes
Patients
title FcγRIIa: A New Cardiovascular Risk Marker
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