Cathodic electrochemiluminescence behaviour of MoS2 quantum dots and its biosensing of microRNA-21

The cathodic electrochemiluminescence (ECL) behaviour of nontoxic MoS 2 quantum dots (QDs) was studied for the first time using potassium peroxydisulfate as the co-reactant. Ag-PAMAM NCs, serving as difunctional tags for quenching and enhancing ECL of MoS 2 -reduced graphene oxide composites, were i...

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Bibliographic Details
Published in:Analyst (London) 2018-08, Vol.143 (15), p.372-377
Main Authors: Cao, Jun-Tao, Liu, Fu-Rao, Hou, Fang, Peng, Juan, Ren, Shu-Wei, Liu, Yan-Ming
Format: Article
Language:English
Subjects:
Chemical analysis
Cobalt
Electrochemiluminescence
MicroRNAs
Molybdenum disulfide
Organic chemistry
Plasma resonance
Potassium persulfate
Quantum dots
Quenching
Ribonucleic acid
RNA
Silver
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Summary:The cathodic electrochemiluminescence (ECL) behaviour of nontoxic MoS 2 quantum dots (QDs) was studied for the first time using potassium peroxydisulfate as the co-reactant. Ag-PAMAM NCs, serving as difunctional tags for quenching and enhancing ECL of MoS 2 -reduced graphene oxide composites, were introduced into the ECL detection system for signal amplification. By modulating the interparticle distance between MoS 2 QDs and Ag-PAMAM NCs, the ECL quenching from resonance energy transfer and the ECL enhancement from surface plasma resonance were realized. Coupling the good ECL performance of MoS 2 QDs with the excellent ECL quenching and enhancement effects of Ag-PAMAM NCs, a novel MoS 2 QDs-based ECL biosensing platform for sensitive detection of microRNA-21 was achieved with a detection limit of 0.20 fmol L −1 (S/N = 3). This method was successfully applied to the determination of microRNA-21 in human serum samples with recoveries of 90.0-110.0%, suggesting great potential for its applications in biological and chemical analysis. The cathodic electrochemiluminescence (ECL) behaviour of nontoxic MoS 2 quantum dots (QDs) was studied for the first time using potassium peroxydisulfate as the co-reactant.
ISSN:0003-2654
1364-5528
DOI:10.1039/c8an00951a