Relation of Subclinical Hypothyroidism is Associated With Cardiovascular Events and All-Cause Mortality in Adults With High Cardiovascular Risk

The aim of this study was to determine the association between subclinical hypothyroidism and cardiovascular (CVD) events, and mortality using the atherosclerotic CVD risk score. We carried out an observational study in a prospective cohort that was followed up for 12 years. The study included 3,021...

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Bibliographic Details
Published in:The American journal of cardiology 2018-08, Vol.122 (4), p.571-577
Main Authors: Moon, Shinje, Kong, Sung Hye, Choi, Hoon Sung, Hwangbo, Yul, Lee, Moon-Kyu, Moon, Jae Hoon, Jang, Hak Chul, Cho, Nam Han, Park, Young Joo
Format: Article
Language:English
Subjects:
Adult
Adults
Age
Aged
Arteriosclerosis
Atherosclerosis
Biomarkers - blood
Cancer
Cardiovascular disease
Cardiovascular diseases
Cardiovascular Diseases - epidemiology
Cardiovascular Diseases - etiology
Cause of Death - trends
Confidence intervals
Epidemiology
Female
Follow-Up Studies
Genomes
Hazards
Health risk assessment
Health risks
Humans
Hypothyroidism
Hypothyroidism - blood
Hypothyroidism - complications
Incidence
Laboratories
Male
Metabolism
Middle Aged
Mortality
Prognosis
Prospective Studies
Regression analysis
Regression models
Republic of Korea - epidemiology
Risk analysis
Risk Factors
Statistical analysis
Subgroups
Survival Rate - trends
Thyroid
Thyroid gland
Thyroid-stimulating hormone
Thyrotropin - blood
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Summary:The aim of this study was to determine the association between subclinical hypothyroidism and cardiovascular (CVD) events, and mortality using the atherosclerotic CVD risk score. We carried out an observational study in a prospective cohort that was followed up for 12 years. The study included 3,021 participants aged ≥ 40 years at baseline from the Ansung cohort, part of the Korean Genome and Epidemiology Study. Cox regression models were constructed to evaluate the hazards ratio (HR) and 95% confidence interval (CI) for all-cause mortality and CVD events in groups classified according to thyroid status. Subgroup analysis was performed with a cut-off age of 65 years or 7.5% of the 10-year atherosclerotic CVD risk score. The subclinical hypothyroidism group in the highest quartile of thyroid-stimulating hormone (>6.57 mIU/L) had a significantly increased risk of all-cause mortality (HR 2.12, 95% CI 1.27 to 3.56) and CVD events (HR 1.92, 95% CI 1.21 to 3.04) compared with euthyroid participants. Subgroup analysis by CVD risk revealed that participants with high CVD risk only had a high risk of all-cause mortality (HR 2.18, 95% CI 1.22 to 3.87) and CVD events (HR 2.42, 95% CI 1.35 to 4.33). Further analysis showed that participants aged
ISSN:0002-9149
1879-1913
DOI:10.1016/j.amjcard.2018.03.371