Effects of acute ingestion of whey protein with or without prior aerobic exercise on postprandial glycemia in type 2 diabetics

• Published in: European journal of applied physiology 2018-09, Vol.118 (9), p.1959-1968
• Main Authors: Cogan, Karl E., Egan, Brendan
• Format: Article
• Language: English
• Subjects: Aerobics; Biomedical and Life Sciences; Biomedicine; Blood glucose; Blood Glucose - metabolism; Diabetes; Diabetes Mellitus, Type 2 - metabolism; Exercise; Exercise - physiology; Female; Glucagon; Glucose; Glucose tolerance; Glucose Tolerance Test; Human Physiology; Humans; Immune response (humoral); Insulin; Insulin - blood; Male; Middle Aged; Occupational Medicine/Industrial Medicine; Original Article; Physical fitness; Postprandial Period - physiology; Protein folding; Proteins; Sports Medicine; Whey protein; Whey Proteins - metabolism
• ISSN: 1439-6319; 1439-6327
• DOI: 10.1007/s00421-018-3931-y

Purpose Acute protein co-ingestion or a single bout of aerobic exercise can attenuate postprandial glycemia, but their combined effect has not been investigated in type 2 diabetics. Methods Using a randomised crossover design, male type 2 diabetics ( n  = 8) [mean (95% CI); age, 55.0 (45.2, 64.8) year; BMI, 33.7 (25.6, 41.8) kg·m − 2 ; 2 h glucose 14.0 (12.5, 15.5) mM] completed (1) 75 g oral glucose tolerance test (OGTT) (CON); (2) OGTT supplemented with 0.33 g·kg BM − 1 of whey protein concentrate (PRO); or OGTT supplemented with PRO but preceded by a bout of aerobic cycling exercise (PRO + EX). Postprandial venous blood samples were collected for glucose, insulin, C-peptide and glucagon. Results Despite a fold-increase of 1.90 (1.26, 2.56; p