Cardiovascular magnetic resonance imaging for amyloidosis: The state-of-the-art

Amyloidosis results from insoluble precursor proteins being deposited in the extracellular compartment. The prognosis of the disease is predominantly determined by cardiac involvement due to amyloid accumulation that contributes to cardiac dysfunction and disturbed conduction of cardiac electrical s...

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Bibliographic Details
Published in:Trends in cardiovascular medicine 2019-02, Vol.29 (2), p.83-94
Main Authors: Tang, Chun Xiang, Petersen, Steffen E., Sanghvi, Mihir M., Lu, Guang Ming, Zhang, Long Jiang
Format: Article
Language:English
Subjects:
Amyloid
Amyloidosis
Cardiac magnetic resonance imaging
Cardiomyopathy
Conduction
Contrast agents
Disease
Edema
Extracellular volume
Gadolinium
Heart diseases
Heart failure
Late gadolinium enhancement
Magnetic resonance imaging
Medical prognosis
Morphology
Mutation
NMR
Nuclear magnetic resonance
T1 mapping
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Summary:Amyloidosis results from insoluble precursor proteins being deposited in the extracellular compartment. The prognosis of the disease is predominantly determined by cardiac involvement due to amyloid accumulation that contributes to cardiac dysfunction and disturbed conduction of cardiac electrical signals. The clinical and radiological manifestations of amyloidosis are often non-specific, making amyloidosis a diagnostic challenge both for clinicians and radiologists. Cardiovascular magnetic resonance imaging, including conventional sequences, late gadolinium enhancement, T1 mapping and determination of extracellular volume fraction is a multi-dimensional modality for the assessment and diagnosis of cardiac amyloidosis and, in addition, is an excellent tool for risk stratification and disease tracking.
ISSN:1050-1738
1873-2615
DOI:10.1016/j.tcm.2018.06.011