Optimised Routines for Monitoring of Treated Late Latent Syphilis Patients

Highly sensitive and specific tests are needed in monitoring of the serological activity and efficacy of treatment of late latent syphilis. In a retrospective study, the data of 52 patients who had received treatment for late latent syphilis were analysed in the Clinical Centre of Skin and Sexually...

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Bibliographic Details
Published in:Proceedings of the Latvian Academy of Sciences. Section B, Natural Sciences Natural Sciences, 2008, Vol.62 (6), p.209-214
Main Authors: Ozoliņš, Dzintars, Hartmane, Ilona, Mikažāns, Ingmārs, Paegle, Daina, Ančupāne, Ināra, Žileviča, Aija
Format: Article
Language:English
Subjects:
diagnostic sensitivity
diagnostic techniques
Disease transmission
immunoglobulin G
Latvia
monitoring
patients
retrospective studies
serological diagnostics
Sexually transmitted diseases
STD
synthetic peptides
Syphilis
treatment monitoring
Treponema pallidum
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Summary:Highly sensitive and specific tests are needed in monitoring of the serological activity and efficacy of treatment of late latent syphilis. In a retrospective study, the data of 52 patients who had received treatment for late latent syphilis were analysed in the Clinical Centre of Skin and Sexually Transmitted Diseases, Latvia. The diagnostic sensitivity and specificity was calculated by Syphilis Immunoblot IgG, Treponema Pallidum Immobilisation Reaction (TPIR) and Syphilis Express Diagnosis (SED). The correlation between Treponema Pallidum Immobilisation Reaction (TPIR) and Syphilis Immunoblot IgG, SED and TPIR results were estimated. Syphilis Immunoblot IgG is useful for latent syphilis diagnostics. The values of the synthetic peptide TmpA, TmpN15 and TmpN47 on the Syphilis Immunoblot IgG strip are useful for monitoring of the treatment of late latent syphilis patients. Vērtējot latenta sifilisa slimības gaitu un serologisko aktivitāti, svarīgi ir izmantot testus ar augstu jutību un specifiskumu. Retrospektīva pētījuma ietvaros Ādas un seksuāli transmisīvo slimību klīniskajā centrā tika analizēti 52 latenta sifilisa pacienti, kuriem bija ordinēta ārstēšana pret sifilisu. Tika aprēķināta sifilisa imunoblota IgG, bālās treponēmas imbilizācijas reakcijas (BTIR) un sifilisa ekspresdiagnostikas testa (SED) jutība un specifitāte. Tika izrēķināta korelācija starp bālās treponēmas imobilizācijas reakcijas (BTIR) un sifilisa imunoblota IgG, SED un bālās treponēmas imobilizācijas reakcijas (BTIR) rezultātiem. Sifilisa imunoblotu IgG ir lietderīgi izmantot latenta sifilisa diagnostikā. Sintētisko peptīdu TmpA, TmpN15 un TmpN47 vērtības uz sifilisa imunoblota IgG stripa ir lietderīgi izmantot latenta sifilisa pacientu ārstēšanas monitorēšanā.
ISSN:1407-009X
2255-890X
DOI:10.2478/v10046-009-0001-1