In situ fluorescence monitoring of diagnosis and treatment: a versatile nanoprobe combining tumor targeting based on MUC1 and controllable DOX release by telomerase

We have constructed versatile drug-loaded nanoprobes capable of responding to both MUC1 and telomerase and achieving intracellular drug release. Besides, the synthesized drug-loaded nanoprobes can realize the in situ imaging observation of the whole process of nanoprobes targeting the tumor cell mem...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2018, Vol.54 (59), p.8277-8280
Main Authors: Si, Haibin, Wang, Lijuan, Li, Qingling, Li, Xiaoxiao, Li, Lu, Tang, Bo
Format: Article
Language:English
Subjects:
Cytoplasm
Drug delivery systems
Fluorescence
Nuclei (cytology)
Telomerase
Tumors
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Summary:We have constructed versatile drug-loaded nanoprobes capable of responding to both MUC1 and telomerase and achieving intracellular drug release. Besides, the synthesized drug-loaded nanoprobes can realize the in situ imaging observation of the whole process of nanoprobes targeting the tumor cell membrane, the transmembrane entering the cytoplasm and the release of DOX into the cell nucleus.
ISSN:1359-7345
1364-548X
DOI:10.1039/c8cc05052j