Eicosapentaenoic Acid and Prevalence of Cardiovascular Disease in Hemodialysis Patients

• Published in: Therapeutic apheresis and dialysis 2018-10, Vol.22 (5), p.514-518
• Main Authors: Honda, Tomoko, Kishi, Satoru, Furukawa, Emi, Ambe, Hiroko, Kurata, Yu, Ichikawa, Masahiro, Aoe, Mari, Ohara, Ken, Furuse, Satoshi, Saito, Katsunori, Nishio, Kyosuke, Masaki, Kazunobu, Kano, Tatsuya, Mise, Naobumi
• Format: Article
• Language: English
• Subjects: Aged; Arachidonic acid; Arachidonic Acid - blood; Brain Ischemia - epidemiology; Cardiovascular disease; Cardiovascular Diseases - blood; Cardiovascular Diseases - epidemiology; Cardiovascular Diseases - physiopathology; Cross-Sectional Studies; Diet; Eicosapentaenoic acid; Eicosapentaenoic Acid - blood; Female; Fish intake; Hemodialysis; Humans; Intracranial Hemorrhages - epidemiology; Logistic Models; Male; Middle Aged; Myocardial Ischemia - epidemiology; Prevalence; Renal Dialysis - methods; Risk Factors; Stroke - epidemiology
• ISSN: 1744-9979; 1744-9987
• DOI: 10.1111/1744-9987.12677

Eicosapentaenoic acid (EPA)/arachidonic acid (AA) ratio showed inverse associations with cardiovascular disease (CVD) in general population. However, this has not been examined enough in dialysis patients. We cross‐sectionally investigated the relationship between EPA/AA ratio and prevalence of CVD in 321 chronic hemodialysis patients (64 ± 11 years old; 110 women; dialysis vintage 10 ± 8 years) in an urban area of Tokyo. CVD was defined as a composite of ischemic heart disease, ischemic stroke and hemorrhagic stroke. The frequency of dietary fish intake was also examined. Logistic regression was used to quantify the association of EPA/AA ratio with CVD. EPA/AA ratio was 0.31 ± 0.19 and 154 patients (48%) consumed fish once or less weekly. One hundred and thirty patients (41%) had CVD, including 65 with ischemic heart disease, 70 with ischemic stroke, and 20 with hemorrhagic stroke. Age (odds ratio [OR], 1.04; P = 0.01), hypertension (OR, 2.25; P = 0.002), and dialysis vintage (OR, 1.04; P = 0.02) were associated with CVD; however, EPA/AA was not after adjustment for other risk factors. A similar relationship was observed between fish intake and CVD prevalence. We did not find any significant association between EPA/AA ratio and prevalence of CVD, although traditional risk factors such as age, hypertension and dialysis vintage were associated with CVD. These results might have been influenced by the fact that only a small proportion of our patients showed a high EPA/AA ratio.