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Voriconazole as mono-therapy in orbitofrontal erosive aspergillosis without gross total resection: A case report and review of literature
•Central nervous system aspergillosis has a poor prognosis.•In immunocompetent patients treated with dual antifungal drugs and surgical resection, mortality can be as high as 66%.•A new voriconazole monotherapy can successfully treat invasive orbitofrontal aspergillosis without surgical resection. I...
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| Published in: | Clinical neurology and neurosurgery 2018-09, Vol.172, p.93-95 |
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| Main Authors: | , , , , , , |
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| cited_by | cdi_FETCH-LOGICAL-c396t-10f179ee57fba76fcf0223479b09a0fd01c39d07d7e48810c415f84502dfffb63 |
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| cites | cdi_FETCH-LOGICAL-c396t-10f179ee57fba76fcf0223479b09a0fd01c39d07d7e48810c415f84502dfffb63 |
| container_end_page | 95 |
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| container_start_page | 93 |
| container_title | Clinical neurology and neurosurgery |
| container_volume | 172 |
| creator | Nowak, Stephan Bollmann, Tom Rosenstengel, Christian Rathmann, Eiko Ribback, Silvia Ewert, Ralf Schroeder, Henry W.S. |
| description | •Central nervous system aspergillosis has a poor prognosis.•In immunocompetent patients treated with dual antifungal drugs and surgical resection, mortality can be as high as 66%.•A new voriconazole monotherapy can successfully treat invasive orbitofrontal aspergillosis without surgical resection.
In this case report we present an immunocompetent 64-year-old patient presenting with an orbitofrontal invasive aspergillosis treated successfully with voriconazole monotherapy following biopsy and orbital decompression. |
| doi_str_mv | 10.1016/j.clineuro.2018.06.043 |
| format | article |
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In this case report we present an immunocompetent 64-year-old patient presenting with an orbitofrontal invasive aspergillosis treated successfully with voriconazole monotherapy following biopsy and orbital decompression.</description><identifier>ISSN: 0303-8467</identifier><identifier>EISSN: 1872-6968</identifier><identifier>DOI: 10.1016/j.clineuro.2018.06.043</identifier><identifier>PMID: 29986203</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Antifungal agents ; Antifungal Agents - therapeutic use ; Aspergillosis ; Aspergillosis - drug therapy ; Aspergillosis - pathology ; Biopsy ; Brain ; Case reports ; Chronic obstructive pulmonary disease ; CNS ; Decompression ; Disease ; Family medical history ; Fungal infections ; Humans ; Immunocompetence - drug effects ; Lung cancer ; Male ; Medical prognosis ; Middle Aged ; Mortality ; Nervous system ; Optic nerve ; Patients ; Pneumonia ; Triazoles - therapeutic use ; Voriconazole ; Voriconazole - therapeutic use</subject><ispartof>Clinical neurology and neurosurgery, 2018-09, Vol.172, p.93-95</ispartof><rights>2018 Elsevier B.V.</rights><rights>Copyright © 2018 Elsevier B.V. All rights reserved.</rights><rights>Copyright Elsevier Limited Sep 2018</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c396t-10f179ee57fba76fcf0223479b09a0fd01c39d07d7e48810c415f84502dfffb63</citedby><cites>FETCH-LOGICAL-c396t-10f179ee57fba76fcf0223479b09a0fd01c39d07d7e48810c415f84502dfffb63</cites><orcidid>0000-0002-0856-6768</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29986203$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nowak, Stephan</creatorcontrib><creatorcontrib>Bollmann, Tom</creatorcontrib><creatorcontrib>Rosenstengel, Christian</creatorcontrib><creatorcontrib>Rathmann, Eiko</creatorcontrib><creatorcontrib>Ribback, Silvia</creatorcontrib><creatorcontrib>Ewert, Ralf</creatorcontrib><creatorcontrib>Schroeder, Henry W.S.</creatorcontrib><title>Voriconazole as mono-therapy in orbitofrontal erosive aspergillosis without gross total resection: A case report and review of literature</title><title>Clinical neurology and neurosurgery</title><addtitle>Clin Neurol Neurosurg</addtitle><description>•Central nervous system aspergillosis has a poor prognosis.•In immunocompetent patients treated with dual antifungal drugs and surgical resection, mortality can be as high as 66%.•A new voriconazole monotherapy can successfully treat invasive orbitofrontal aspergillosis without surgical resection.
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| ispartof | Clinical neurology and neurosurgery, 2018-09, Vol.172, p.93-95 |
| issn | 0303-8467 1872-6968 |
| language | eng |
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| source | Elsevier |
| subjects | Antifungal agents Antifungal Agents - therapeutic use Aspergillosis Aspergillosis - drug therapy Aspergillosis - pathology Biopsy Brain Case reports Chronic obstructive pulmonary disease CNS Decompression Disease Family medical history Fungal infections Humans Immunocompetence - drug effects Lung cancer Male Medical prognosis Middle Aged Mortality Nervous system Optic nerve Patients Pneumonia Triazoles - therapeutic use Voriconazole Voriconazole - therapeutic use |
| title | Voriconazole as mono-therapy in orbitofrontal erosive aspergillosis without gross total resection: A case report and review of literature |
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