Reversible Posterior Leukoencephalopathy Syndrome in 2 HIV-Infected Patients Receiving Antiretroviral Therapy

We describe 2 human immunodeficiency virus- infected patients who developed hypertension and severe neurological abnormalities while receiving successful antiretroviral therapy. Neuroimaging findings were characteristic of reversible posterior leukoencephalopathy syndrome, a brain-capillary leak syn...

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Bibliographic Details
Published in:Clinical infectious diseases 2008-01, Vol.46 (2), p.e19-e22
Main Authors: Ridolfo, Anna Lisa, Resta, Federico, Milazzo, Laura, Caramma, Ilaria, Matacena, Giovanni, Antinori, Spinello, Galli, Massimo
Format: Article
Language:English
Subjects:
Adult
Anti-Retroviral Agents - administration & dosage
Anti-Retroviral Agents - adverse effects
Endothelium, Vascular - drug effects
Endothelium, Vascular - pathology
HIV Infections - complications
HIV Infections - drug therapy
HIV Infections - virology
Human immunodeficiency virus
Humans
Hypertension - chemically induced
Hypertension - virology
Male
Middle Aged
Posterior Leukoencephalopathy Syndrome - chemically induced
Posterior Leukoencephalopathy Syndrome - virology
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Summary:We describe 2 human immunodeficiency virus- infected patients who developed hypertension and severe neurological abnormalities while receiving successful antiretroviral therapy. Neuroimaging findings were characteristic of reversible posterior leukoencephalopathy syndrome, a brain-capillary leak syndrome with hypertension and endothelial damage. We discuss the role of antiretroviral therapy-associated metabolic alterations in endothelial damage, hypertension, and reversible posterior leukoencephalopathy syndrome.
ISSN:1058-4838
1537-6591
DOI:10.1086/524740