Predictive Role of the Cervical Sympathetic Trunk Ischemia on Lower Heart Rates in an Experimentally Induced Stenoocclusive Carotid Artery Model by Bilateral Common Carotid Artery Ligation

Bilateral common carotid artery ligation (BCCAL) leads to acute craniocervicocerebral ischemia, retrograde blood flow, increased blood pressure, and significant hemodynamic and histomorphological changes at the posterior cerebral vasculature. We examined the potential relationship between denervatio...

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Bibliographic Details
Published in:Cardiovascular toxicology 2019-02, Vol.19 (1), p.56-61
Main Authors: Koza, Yavuzer, Bayram, Ednan, Aydin, Mehmet Dumlu, Atalay, Canan, Onen, Mehmet Resit, Ozturk, Cengiz, Sipal, Sare, Demirci, Elif, Levent, Akin
Format: Article
Language:English
Subjects:
Analysis
Biomedical and Life Sciences
Biomedicine
Blood flow
Blood pressure
Cardiology
Carotid arteries
Carotid artery
Denervation
Density
Ganglia
Heart beat
Heart rate
Ischemia
Neurons
Pharmacology/Toxicology
Rabbits
Stellate ganglion
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Summary:Bilateral common carotid artery ligation (BCCAL) leads to acute craniocervicocerebral ischemia, retrograde blood flow, increased blood pressure, and significant hemodynamic and histomorphological changes at the posterior cerebral vasculature. We examined the potential relationship between denervation injury following BCCAL-induced cervical sympathetic trunk (CST) ischemia and heart rate after permanent BCCAL. Rabbits ( n  = 25) were randomly divided into three groups: an unoperated control group (GI, n  = 6); a sham-operated control group (GII, n  = 6), and an experimental group subjected to BCCAL (GIII, n  = 13); and then followed for one month. All animals were then sacrificed and the stellate ganglia (STGs) were examined histologically using stereological methods. The densities of degenerated neurons in the STGs were compared with heart rates and the results were analyzed with the Mann–Whitney U test. The mean normal neuron density in STGs was 10.340 ± 954/mm 3 and the degenerated neuron density was 12 ± 3/mm 3 in the GI group ( p  > 0.5). The mean heart rates and degenerated neuron densities of STGs were recorded as 267 ± 19/min and 237 ± 45/mm 3 in GII ( p  
ISSN:1530-7905
1559-0259
DOI:10.1007/s12012-018-9473-z