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Predictive Role of the Cervical Sympathetic Trunk Ischemia on Lower Heart Rates in an Experimentally Induced Stenoocclusive Carotid Artery Model by Bilateral Common Carotid Artery Ligation
Bilateral common carotid artery ligation (BCCAL) leads to acute craniocervicocerebral ischemia, retrograde blood flow, increased blood pressure, and significant hemodynamic and histomorphological changes at the posterior cerebral vasculature. We examined the potential relationship between denervatio...
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| Published in: | Cardiovascular toxicology 2019-02, Vol.19 (1), p.56-61 |
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| container_start_page | 56 |
| container_title | Cardiovascular toxicology |
| container_volume | 19 |
| creator | Koza, Yavuzer Bayram, Ednan Aydin, Mehmet Dumlu Atalay, Canan Onen, Mehmet Resit Ozturk, Cengiz Sipal, Sare Demirci, Elif Levent, Akin |
| description | Bilateral common carotid artery ligation (BCCAL) leads to acute craniocervicocerebral ischemia, retrograde blood flow, increased blood pressure, and significant hemodynamic and histomorphological changes at the posterior cerebral vasculature. We examined the potential relationship between denervation injury following BCCAL-induced cervical sympathetic trunk (CST) ischemia and heart rate after permanent BCCAL. Rabbits (
n
= 25) were randomly divided into three groups: an unoperated control group (GI,
n
= 6); a sham-operated control group (GII,
n
= 6), and an experimental group subjected to BCCAL (GIII,
n
= 13); and then followed for one month. All animals were then sacrificed and the stellate ganglia (STGs) were examined histologically using stereological methods. The densities of degenerated neurons in the STGs were compared with heart rates and the results were analyzed with the Mann–Whitney
U
test. The mean normal neuron density in STGs was 10.340 ± 954/mm
3
and the degenerated neuron density was 12 ± 3/mm
3
in the GI group (
p
> 0.5). The mean heart rates and degenerated neuron densities of STGs were recorded as 267 ± 19/min and 237 ± 45/mm
3
in GII (
p
|
| doi_str_mv | 10.1007/s12012-018-9473-z |
| format | article |
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n
= 25) were randomly divided into three groups: an unoperated control group (GI,
n
= 6); a sham-operated control group (GII,
n
= 6), and an experimental group subjected to BCCAL (GIII,
n
= 13); and then followed for one month. All animals were then sacrificed and the stellate ganglia (STGs) were examined histologically using stereological methods. The densities of degenerated neurons in the STGs were compared with heart rates and the results were analyzed with the Mann–Whitney
U
test. The mean normal neuron density in STGs was 10.340 ± 954/mm
3
and the degenerated neuron density was 12 ± 3/mm
3
in the GI group (
p
> 0.5). The mean heart rates and degenerated neuron densities of STGs were recorded as 267 ± 19/min and 237 ± 45/mm
3
in GII (
p
< 0.005 for GII vs. GI); and 190 ± 11/min 1421 ± 230/mm
3
in GIII (
p
< 0.0001 for GIII vs. GI and
p
< 0.005 for GIII vs. GII). An inverse and meaningful association was observed between the heart rate and degenerated neuronal density in the STGs. BCCAL may lead to hazardous histomorphological changes in the CST. A high density of degenerated neurons in the STG may provoke excessive sympathetic hypoactivity-related cardiac damage and bradyarrhythmias after stenoocclusive carotid artery diseases.</description><identifier>ISSN: 1530-7905</identifier><identifier>EISSN: 1559-0259</identifier><identifier>DOI: 10.1007/s12012-018-9473-z</identifier><identifier>PMID: 29992494</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Analysis ; Biomedical and Life Sciences ; Biomedicine ; Blood flow ; Blood pressure ; Cardiology ; Carotid arteries ; Carotid artery ; Denervation ; Density ; Ganglia ; Heart beat ; Heart rate ; Ischemia ; Neurons ; Pharmacology/Toxicology ; Rabbits ; Stellate ganglion</subject><ispartof>Cardiovascular toxicology, 2019-02, Vol.19 (1), p.56-61</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2018</rights><rights>COPYRIGHT 2019 Springer</rights><rights>Cardiovascular Toxicology is a copyright of Springer, (2018). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c439t-87a40c1a9d0948c19d5d782c954c032fb001aa8b78f451288517c6a2b598c9273</citedby><cites>FETCH-LOGICAL-c439t-87a40c1a9d0948c19d5d782c954c032fb001aa8b78f451288517c6a2b598c9273</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29992494$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Koza, Yavuzer</creatorcontrib><creatorcontrib>Bayram, Ednan</creatorcontrib><creatorcontrib>Aydin, Mehmet Dumlu</creatorcontrib><creatorcontrib>Atalay, Canan</creatorcontrib><creatorcontrib>Onen, Mehmet Resit</creatorcontrib><creatorcontrib>Ozturk, Cengiz</creatorcontrib><creatorcontrib>Sipal, Sare</creatorcontrib><creatorcontrib>Demirci, Elif</creatorcontrib><creatorcontrib>Levent, Akin</creatorcontrib><title>Predictive Role of the Cervical Sympathetic Trunk Ischemia on Lower Heart Rates in an Experimentally Induced Stenoocclusive Carotid Artery Model by Bilateral Common Carotid Artery Ligation</title><title>Cardiovascular toxicology</title><addtitle>Cardiovasc Toxicol</addtitle><addtitle>Cardiovasc Toxicol</addtitle><description>Bilateral common carotid artery ligation (BCCAL) leads to acute craniocervicocerebral ischemia, retrograde blood flow, increased blood pressure, and significant hemodynamic and histomorphological changes at the posterior cerebral vasculature. We examined the potential relationship between denervation injury following BCCAL-induced cervical sympathetic trunk (CST) ischemia and heart rate after permanent BCCAL. Rabbits (
n
= 25) were randomly divided into three groups: an unoperated control group (GI,
n
= 6); a sham-operated control group (GII,
n
= 6), and an experimental group subjected to BCCAL (GIII,
n
= 13); and then followed for one month. All animals were then sacrificed and the stellate ganglia (STGs) were examined histologically using stereological methods. The densities of degenerated neurons in the STGs were compared with heart rates and the results were analyzed with the Mann–Whitney
U
test. The mean normal neuron density in STGs was 10.340 ± 954/mm
3
and the degenerated neuron density was 12 ± 3/mm
3
in the GI group (
p
> 0.5). The mean heart rates and degenerated neuron densities of STGs were recorded as 267 ± 19/min and 237 ± 45/mm
3
in GII (
p
< 0.005 for GII vs. GI); and 190 ± 11/min 1421 ± 230/mm
3
in GIII (
p
< 0.0001 for GIII vs. GI and
p
< 0.005 for GIII vs. GII). An inverse and meaningful association was observed between the heart rate and degenerated neuronal density in the STGs. BCCAL may lead to hazardous histomorphological changes in the CST. A high density of degenerated neurons in the STG may provoke excessive sympathetic hypoactivity-related cardiac damage and bradyarrhythmias after stenoocclusive carotid artery diseases.</description><subject>Analysis</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Blood flow</subject><subject>Blood pressure</subject><subject>Cardiology</subject><subject>Carotid arteries</subject><subject>Carotid artery</subject><subject>Denervation</subject><subject>Density</subject><subject>Ganglia</subject><subject>Heart beat</subject><subject>Heart rate</subject><subject>Ischemia</subject><subject>Neurons</subject><subject>Pharmacology/Toxicology</subject><subject>Rabbits</subject><subject>Stellate ganglion</subject><issn>1530-7905</issn><issn>1559-0259</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp1kl1vFCEUhidGYz_0B3hjSLzxZiowwwKX66a2m6zRtPWasMyZLZWBFZjq9rf542Sy1cZGwwXk8Lzv4eOtqlcEnxCM-btEKCa0xkTUsuVNffekOiSMyRpTJp9O6wbXXGJ2UB2ldIMxpXTGnlcHVEpJW9keVj8_R-isyfYW0EVwgEKP8jWgBcRba7RDl7thq0slW4Ou4ui_omUy1zBYjYJHq_AdIjoHHTO60BkSsh5pj05_bCHaAXzWzu3Q0nejgQ5dZvAhGOPGNDVc6Biy7dA8Zog79DF04NB6h95bV7xi6b4Iw1DaPAJXdqOzDf5F9azXLsHL-_m4-vLh9GpxXq8-nS0X81Vt2kbmWnDdYkO07LBshSGyYx0X1EjWGtzQfo0x0VqsuehbRqgQjHAz03TNpDCS8ua4erv33cbwbYSU1WCTAee0hzAmRfFMNG3Dm6agbx6hN2GMvpxuojjDrGHkgdpoB8r6PuSozWSq5pwILKVoaKFO_kGV0ZXnN8FDb0v9LwHZC0wMKUXo1bZ8go47RbCaEqP2iVElMWpKjLormtf3Bx7XA3R_FL8jUgC6B1LZ8huIDzf6v-svtlnMZw</recordid><startdate>20190201</startdate><enddate>20190201</enddate><creator>Koza, Yavuzer</creator><creator>Bayram, Ednan</creator><creator>Aydin, Mehmet Dumlu</creator><creator>Atalay, Canan</creator><creator>Onen, Mehmet Resit</creator><creator>Ozturk, Cengiz</creator><creator>Sipal, Sare</creator><creator>Demirci, Elif</creator><creator>Levent, Akin</creator><general>Springer US</general><general>Springer</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>20190201</creationdate><title>Predictive Role of the Cervical Sympathetic Trunk Ischemia on Lower Heart Rates in an Experimentally Induced Stenoocclusive Carotid Artery Model by Bilateral Common Carotid Artery Ligation</title><author>Koza, Yavuzer ; Bayram, Ednan ; Aydin, Mehmet Dumlu ; Atalay, Canan ; Onen, Mehmet Resit ; Ozturk, Cengiz ; Sipal, Sare ; Demirci, Elif ; Levent, Akin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c439t-87a40c1a9d0948c19d5d782c954c032fb001aa8b78f451288517c6a2b598c9273</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Analysis</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Blood flow</topic><topic>Blood pressure</topic><topic>Cardiology</topic><topic>Carotid arteries</topic><topic>Carotid artery</topic><topic>Denervation</topic><topic>Density</topic><topic>Ganglia</topic><topic>Heart beat</topic><topic>Heart rate</topic><topic>Ischemia</topic><topic>Neurons</topic><topic>Pharmacology/Toxicology</topic><topic>Rabbits</topic><topic>Stellate ganglion</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Koza, Yavuzer</creatorcontrib><creatorcontrib>Bayram, Ednan</creatorcontrib><creatorcontrib>Aydin, Mehmet Dumlu</creatorcontrib><creatorcontrib>Atalay, Canan</creatorcontrib><creatorcontrib>Onen, Mehmet Resit</creatorcontrib><creatorcontrib>Ozturk, Cengiz</creatorcontrib><creatorcontrib>Sipal, Sare</creatorcontrib><creatorcontrib>Demirci, Elif</creatorcontrib><creatorcontrib>Levent, Akin</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Cardiovascular toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Koza, Yavuzer</au><au>Bayram, Ednan</au><au>Aydin, Mehmet Dumlu</au><au>Atalay, Canan</au><au>Onen, Mehmet Resit</au><au>Ozturk, Cengiz</au><au>Sipal, Sare</au><au>Demirci, Elif</au><au>Levent, Akin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Predictive Role of the Cervical Sympathetic Trunk Ischemia on Lower Heart Rates in an Experimentally Induced Stenoocclusive Carotid Artery Model by Bilateral Common Carotid Artery Ligation</atitle><jtitle>Cardiovascular toxicology</jtitle><stitle>Cardiovasc Toxicol</stitle><addtitle>Cardiovasc Toxicol</addtitle><date>2019-02-01</date><risdate>2019</risdate><volume>19</volume><issue>1</issue><spage>56</spage><epage>61</epage><pages>56-61</pages><issn>1530-7905</issn><eissn>1559-0259</eissn><abstract>Bilateral common carotid artery ligation (BCCAL) leads to acute craniocervicocerebral ischemia, retrograde blood flow, increased blood pressure, and significant hemodynamic and histomorphological changes at the posterior cerebral vasculature. We examined the potential relationship between denervation injury following BCCAL-induced cervical sympathetic trunk (CST) ischemia and heart rate after permanent BCCAL. Rabbits (
n
= 25) were randomly divided into three groups: an unoperated control group (GI,
n
= 6); a sham-operated control group (GII,
n
= 6), and an experimental group subjected to BCCAL (GIII,
n
= 13); and then followed for one month. All animals were then sacrificed and the stellate ganglia (STGs) were examined histologically using stereological methods. The densities of degenerated neurons in the STGs were compared with heart rates and the results were analyzed with the Mann–Whitney
U
test. The mean normal neuron density in STGs was 10.340 ± 954/mm
3
and the degenerated neuron density was 12 ± 3/mm
3
in the GI group (
p
> 0.5). The mean heart rates and degenerated neuron densities of STGs were recorded as 267 ± 19/min and 237 ± 45/mm
3
in GII (
p
< 0.005 for GII vs. GI); and 190 ± 11/min 1421 ± 230/mm
3
in GIII (
p
< 0.0001 for GIII vs. GI and
p
< 0.005 for GIII vs. GII). An inverse and meaningful association was observed between the heart rate and degenerated neuronal density in the STGs. BCCAL may lead to hazardous histomorphological changes in the CST. A high density of degenerated neurons in the STG may provoke excessive sympathetic hypoactivity-related cardiac damage and bradyarrhythmias after stenoocclusive carotid artery diseases.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>29992494</pmid><doi>10.1007/s12012-018-9473-z</doi><tpages>6</tpages></addata></record> |
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| subjects | Analysis Biomedical and Life Sciences Biomedicine Blood flow Blood pressure Cardiology Carotid arteries Carotid artery Denervation Density Ganglia Heart beat Heart rate Ischemia Neurons Pharmacology/Toxicology Rabbits Stellate ganglion |
| title | Predictive Role of the Cervical Sympathetic Trunk Ischemia on Lower Heart Rates in an Experimentally Induced Stenoocclusive Carotid Artery Model by Bilateral Common Carotid Artery Ligation |
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