Synthesis and antimicrobial activity of substituted amides and hydrazides of N-acyl-5-bromanthranilic acids

A series of 17 new substituted amides and hydrazides of N-acyl-5-bromanthranilic acids were synthesized. The antimicrobial activity of these compounds with respect to St. aureus and E. coli was evaluated. It was found that of N-chloracetyl-5-bromanthranlic acid methylamide and hydrazide significantl...

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Published in:Pharmaceutical chemistry journal 2007-09, Vol.41 (9), p.483-485
Main Authors: Andryukov, K. V., Tomilov, M. V., Korkodinova, L. M., Odegova, T. F.
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Language:English
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Escherichia coli
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description A series of 17 new substituted amides and hydrazides of N-acyl-5-bromanthranilic acids were synthesized. The antimicrobial activity of these compounds with respect to St. aureus and E. coli was evaluated. It was found that of N-chloracetyl-5-bromanthranlic acid methylamide and hydrazide significantly suppressed the growth of test microbes, with a minimum inhibitory concentration of 15.6 mg/ml against St. aureus and 15.6-31.5 mg/ml against E. coli. The other tested compounds were significantly less active.
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subjects Escherichia coli
title Synthesis and antimicrobial activity of substituted amides and hydrazides of N-acyl-5-bromanthranilic acids
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