Do bednets including piperonyl butoxide offer additional protection against populations of Anopheles gambiae s.l. that are highly resistant to pyrethroids? An experimental hut evaluation in Burkina Fasov

Malaria control is dependent on the use of longlasting insecticidal nets (LLINs) containing pyrethroids. A new generation of LLINs containing both pyrethroids and the synergist piperonyl butoxide (PBO) has been developed in response to increasing pyrethroid resistance in African malaria vectors, but...

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Bibliographic Details
Published in:Medical and veterinary entomology 2018-12, Vol.32 (4), p.407-416
Main Authors: Toe, K. H., Müller, P., Badolo, A., Traore, A., Sagnon, N., Dabiré, R. K., Ranson, H.
Format: Article
Language:English
Subjects:
Animals
Anopheles - genetics
Anopheles gambiae
Biological Assay
Burkina Faso
Culicidae
Deltamethrin
DNA - genetics
DNA - isolation & purification
Female
Housing
Humans
Insecticide Resistance
insecticide resistance management
Insecticide-Treated Bednets
Insecticides
longlasting insecticidal nets
Malaria
Malaria - prevention & control
Male
Mortality
Mutation
Nets
PBO
Permethrin
Piperonyl Butoxide
Pyrethrins
Pyrethroids
RNA - analysis
RNA - isolation & purification
Transcriptome
Vectors
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Summary:Malaria control is dependent on the use of longlasting insecticidal nets (LLINs) containing pyrethroids. A new generation of LLINs containing both pyrethroids and the synergist piperonyl butoxide (PBO) has been developed in response to increasing pyrethroid resistance in African malaria vectors, but questions remain about the performance of these nets in areas where levels of pyrethroid resistance are very high. This study was conducted in two settings in southwest Burkina Faso, Vallée du Kou 5 and Tengrela, where Anopheles gambiae s.l. (Diptera: Culicidae) mortality rates in World Health Organization (WHO) discriminating dose assays were
ISSN:0269-283X
1365-2915
DOI:10.1111/mve.12316