Efficacy of inactivated autologous porous bone flap and BAM bone-induced artificial bone for repairing skull defect in rats

To study the effect of BAM bone grafting combined with inactivated autologous porous bone flap in repairing skull defect in rats. Seventy-two Wistar rats with skull defect were randomly divided into control group, inactivated autologous bone flap group (AB group), BAM bone-induced artificial bone ma...

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Bibliographic Details
Published in:Nan fang yi ke da xue xue bao = Journal of Southern Medical University 2018-06, Vol.38 (6), p.748-754
Main Authors: Wang, Chao-Min, Liu, Tie-Jian, Song, Zhen-Hua, Guo, Xiao-Yu, Wei, Da-Nian, Liu, Cheng-Yong
Format: Article
Language:Chinese
Subjects:
Animals
Bone Regeneration - physiology
Bone Substitutes
Bone Transplantation - methods
Osteogenesis - physiology
Random Allocation
Rats
Rats, Wistar
Skull - injuries
Skull - surgery
Wound Healing - physiology
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Summary:To study the effect of BAM bone grafting combined with inactivated autologous porous bone flap in repairing skull defect in rats. Seventy-two Wistar rats with skull defect were randomly divided into control group, inactivated autologous bone flap group (AB group), BAM bone-induced artificial bone material group (BAM group), and inactivated autologous bone flap with BAM bone-induced artificial bone group (BAM+AB group). The bone healing was evaluated with micro-CT and the new bone formation was assessed with histological staining at 1, 2, and 3 months after modeling. Inactivated porous bone flap combined with BAM bone-induced artificial bone effectively induced vascular and fibrous tissue regeneration and osteogenesis in the cranial defects. With the inactivated porous bone flap as the scaffold, BAM bone-induced artificial bone obviously promoted the restoration of the skull appearance in the rats with cranial defects. Inactivated autologous bone flap group and BAM bone-induced artificial bone material can pro
ISSN:1673-4254