Effect of itopride on gastric emptying in longstanding diabetes mellitus

Delayed gastric emptying (GE) occurs in 30–50% of patients with longstanding type 1 or 2 diabetes, and represents a major cause of morbidity. Current therapeutic options are limited. We aimed at evaluating the effects of itopride on GE in patients with longstanding diabetes. Twenty‐five patients (20...

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Bibliographic Details
Published in:Neurogastroenterology and motility 2008-05, Vol.20 (5), p.456-463
Main Authors: Stevens, J. E., Russo, A., Maddox, A. F., Rayner, C. K., Phillips, L., Talley, N. J., Giguère, M., Horowitz, M., Jones, K. L.
Format: Article
Language:English
Subjects:
Adult
Benzamides - pharmacology
Benzamides - therapeutic use
Benzyl Compounds - pharmacology
Benzyl Compounds - therapeutic use
Blood Glucose - drug effects
Blood Glucose - physiology
Cross-Over Studies
diabetes
Diabetes Mellitus - blood
Diabetes Mellitus - drug therapy
Diabetes Mellitus - physiopathology
Double-Blind Method
Female
gastric emptying
Gastric Emptying - drug effects
Gastric Emptying - physiology
Humans
itopride
Male
Middle Aged
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Summary:Delayed gastric emptying (GE) occurs in 30–50% of patients with longstanding type 1 or 2 diabetes, and represents a major cause of morbidity. Current therapeutic options are limited. We aimed at evaluating the effects of itopride on GE in patients with longstanding diabetes. Twenty‐five patients (20 type 1, 5 type 2; 10 males, 15 females; mean age 45.2 ± 2.7 years; body mass index 27.5 ± 0.9 kg m−2; duration of diabetes 20.2 ± 2.4 years) were enrolled in a double‐blind, placebo‐controlled, randomized, crossover trial. Subjects received both itopride (200 mg) and placebo t.i.d. for 7 days, with a washout of 7–14 days. GE (scintigraphy), blood glucose (glucometer) and upper gastrointestinal (GI) symptoms (questionnaire) were measured following each treatment period. The test meal comprised 100 g ground beef (99mTc‐sulphur colloid) and 150 mL of 10% dextrose [67Ga‐ethylenediaminetetraacetic acid (EDTA)]. There was a slight trend for itopride to accelerate both solid (P = 0.09) and liquid (P = 0.09) GE. With itopride treatment, the emptying of both solids and liquids tended to be more accelerated, as the emptying with placebo was slower (solids: r = 0.39, P = 0.057; liquids: r = 0.44, P 
ISSN:1350-1925
1365-2982
DOI:10.1111/j.1365-2982.2007.01058.x