Voxel-Based Analysis of Gray Matter and CSF Space in Idiopathic Normal Pressure Hydrocephalus

Aims: To investigate regional morphologic changes in idiopathic normal pressure hydrocephalus (INPH) based on diagnosis with INPH Guidelines using voxel-based morphometry. Method: Three-dimensional magnetic resonance imaging was performed in 34 INPH patients, who met probable INPH criteria, probable...

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Bibliographic Details
Published in:Dementia and geriatric cognitive disorders 2008-01, Vol.25 (4), p.329-335
Main Authors: Ishii, Kazunari, Kawaguchi, Tetsuro, Shimada, Kenichi, Ohkawa, Shingo, Miyamoto, Naokazu, Kanda, Tomonori, Uemura, Takafumi, Yoshikawa, Toshiki, Mori, Etsuro
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Alzheimer Disease - cerebrospinal fluid
Alzheimer Disease - pathology
Biological and medical sciences
Brain Mapping - methods
Caudate Nucleus - pathology
Cerebrospinal Fluid
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Female
Frontal Lobe - pathology
Humans
Hydrocephalus, Normal Pressure - cerebrospinal fluid
Hydrocephalus, Normal Pressure - pathology
Imaging, Three-Dimensional
Magnetic Resonance Imaging - methods
Magnetic Resonance Imaging - standards
Male
Medical sciences
Neurology
Original Research Article
Parietal Lobe - pathology
Practice Guidelines as Topic
Thalamus - pathology
Vascular diseases and vascular malformations of the nervous system
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Summary:Aims: To investigate regional morphologic changes in idiopathic normal pressure hydrocephalus (INPH) based on diagnosis with INPH Guidelines using voxel-based morphometry. Method: Three-dimensional magnetic resonance imaging was performed in 34 INPH patients, who met probable INPH criteria, probable 34 Alzheimer disease patients, and 34 normal control subjects. Results: Statistical parametric mapping was used to conduct voxel-based morphometry analysis of the morphologic data and revealed enlarged ventricles and sylvian fissures and stenotic sulci of high convexity, especially in the precuneus in the INPH group, with decreased gray matter density in the insula, caudate and thalamus. Conclusion: In INPH, morphologic change occurs in the frontoparietal high convexity with ventricular dilatations, dilated sylvian fissures and tight sulci in the medial parietal lobes.
ISSN:1420-8008
1421-9824
DOI:10.1159/000119521