Anthraquinones from the roots of Prismatomeris malayana

A novel anthraquinone, 1,3-dihydroxy-5,6-dimethoxy-2-methoxymethyl-9,10-anthraquinone (9) and a new natural product, 2-hydroxymethyl-1-methoxy-9,10-anthraquinone (8) were isolated from the roots of Prismatomeris malayana together with seven known anthraquinones, tectoquinone (1), 1-hydroxy-2-methyl-...

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Bibliographic Details
Published in:Natural product research 2008-07, Vol.22 (11), p.962-968
Main Authors: Tuntiwachwuttikul, Pittaya, Butsuri, Yuttapon, Sukkoet, Piyanut, Prawat, Uma, Taylor, Walter Charles
Format: Article
Language:English
Subjects:
Aldehydes - chemistry
Aldehydes - pharmacology
Animals
Anthraquinones
Anthraquinones - chemistry
Anthraquinones - pharmacology
Antifungal Agents - chemistry
Antifungal Agents - pharmacology
Antimalarials - chemistry
Antimalarials - pharmacology
Antineoplastic Agents - chemistry
Antineoplastic Agents - pharmacology
Candida albicans - drug effects
Cell Line, Tumor
Cell Proliferation - drug effects
Humans
Magnetic Resonance Spectroscopy
Molecular Structure
Plant Roots - chemistry
Plasmodium falciparum - drug effects
Prismatomeris malayana
Rubiaceae
Rubiaceae - chemistry
Spectroscopy, Fourier Transform Infrared
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Summary:A novel anthraquinone, 1,3-dihydroxy-5,6-dimethoxy-2-methoxymethyl-9,10-anthraquinone (9) and a new natural product, 2-hydroxymethyl-1-methoxy-9,10-anthraquinone (8) were isolated from the roots of Prismatomeris malayana together with seven known anthraquinones, tectoquinone (1), 1-hydroxy-2-methyl-9,10-anthraquinone (2), rubiadin (3), rubiadin-1-methyl ether (4), 1,3-dihydroxy-5,6-dimethoxy-2-methyl-9,10-anthraquinone (5), nordamnacanthal (6), and damnacanthal (7). Their structures were determined on the basis of spectroscopic data. Some of the anthraquinones were tested for anticancer, antifungal, and antimalarial activities.
ISSN:1478-6419
1478-6427
DOI:10.1080/14786410701650261