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Toxicological reproductive study of Cassia occidentalis L. in female Wistar rats
Cassia occidentalis L. (Leguminosae) has long been used as natural medicine in rainforests and other tropical regions for the treatment of inflammation, fever, liver disorders, constipation, worms, fungal infections, ulcers, respiratory infections, snakebite and as a potent abortifacient. This study...
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| Published in: | Journal of ethnopharmacology 2009-05, Vol.123 (1), p.163-166 |
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| Main Authors: | , , , , , , , , , , |
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| container_end_page | 166 |
| container_issue | 1 |
| container_start_page | 163 |
| container_title | Journal of ethnopharmacology |
| container_volume | 123 |
| creator | Aragão, T.P. Lyra, M.M.A. Silva, M.G.B. Andrade, B.A. Ferreira, P.A. Ortega, L.F. da Silva, S.D. da Silva, J.C.P. Fraga, M.C.C.A. Wanderley, A.G. Lafayette, S.S.L. |
| description | Cassia occidentalis L. (Leguminosae) has long been used as natural medicine in rainforests and other tropical regions for the treatment of inflammation, fever, liver disorders, constipation, worms, fungal infections, ulcers, respiratory infections, snakebite and as a potent abortifacient.
This study has investigated the effects of oral sub-acute administration of
Cassia occidentalis during pregnancy in female Wistar rats.
Three groups of pregnant rats were treated orally from the 1st to the 6th day (pre-implantation period) and from the 7th to the 14th day (organogenic period) of pregnancy, with doses of 250 and 500
mg/kg. On the 20th day of pregnancy, the animals were euthanized and reproductive parameters evaluated.
The results revealed no statistically significant differences between the control and treated groups in terms of offspring/dam relationship; fetuses, placentae and ovaries weights; number of implantation and resorption sites; number of corpora lutea in the ovaries and pre- and post-implantation loss rates. However, the presence of dead fetuses was registered in both doses of 250 and 500
mg/kg of
Cassia occidentalis.
Further studies should therefore be conducted to obtain more detailed characteristics of the toxic effects of this species, the use of which is not recommended during pregnancy. |
| doi_str_mv | 10.1016/j.jep.2008.11.030 |
| format | article |
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This study has investigated the effects of oral sub-acute administration of
Cassia occidentalis during pregnancy in female Wistar rats.
Three groups of pregnant rats were treated orally from the 1st to the 6th day (pre-implantation period) and from the 7th to the 14th day (organogenic period) of pregnancy, with doses of 250 and 500
mg/kg. On the 20th day of pregnancy, the animals were euthanized and reproductive parameters evaluated.
The results revealed no statistically significant differences between the control and treated groups in terms of offspring/dam relationship; fetuses, placentae and ovaries weights; number of implantation and resorption sites; number of corpora lutea in the ovaries and pre- and post-implantation loss rates. However, the presence of dead fetuses was registered in both doses of 250 and 500
mg/kg of
Cassia occidentalis.
Further studies should therefore be conducted to obtain more detailed characteristics of the toxic effects of this species, the use of which is not recommended during pregnancy.</description><identifier>ISSN: 0378-8741</identifier><identifier>EISSN: 1872-7573</identifier><identifier>DOI: 10.1016/j.jep.2008.11.030</identifier><identifier>PMID: 19429356</identifier><identifier>CODEN: JOETD7</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>adverse effects ; Animals ; Biological and medical sciences ; Cassia occidentalis ; Cassia occidentalis L ; corpus luteum ; Dose-Response Relationship, Drug ; embryo implantation ; Fabaceae ; Fedegoso ; Female ; females ; Fetal Death ; fetus ; General pharmacology ; genotoxicity ; Leguminosae ; litter size ; Medical sciences ; medicinal plants ; medicinal properties ; mutagenicity ; oral administration ; organogenesis ; ovaries ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; placenta ; Plant Extracts - toxicity ; Pregnancy ; Rats ; Rats, Wistar ; Reproduction - drug effects ; reproductive toxicology ; Senna occidentalis ; Senna Plant - chemistry ; subacute toxicity ; temporal variation ; tissue weight ; Toxicology</subject><ispartof>Journal of ethnopharmacology, 2009-05, Vol.123 (1), p.163-166</ispartof><rights>2009</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c467t-be1cd8fec83a84885ffbf842a6d1ff8bf2459d12a972fcd5aeca260b784b9f2b3</citedby><cites>FETCH-LOGICAL-c467t-be1cd8fec83a84885ffbf842a6d1ff8bf2459d12a972fcd5aeca260b784b9f2b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21465313$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19429356$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Aragão, T.P.</creatorcontrib><creatorcontrib>Lyra, M.M.A.</creatorcontrib><creatorcontrib>Silva, M.G.B.</creatorcontrib><creatorcontrib>Andrade, B.A.</creatorcontrib><creatorcontrib>Ferreira, P.A.</creatorcontrib><creatorcontrib>Ortega, L.F.</creatorcontrib><creatorcontrib>da Silva, S.D.</creatorcontrib><creatorcontrib>da Silva, J.C.P.</creatorcontrib><creatorcontrib>Fraga, M.C.C.A.</creatorcontrib><creatorcontrib>Wanderley, A.G.</creatorcontrib><creatorcontrib>Lafayette, S.S.L.</creatorcontrib><title>Toxicological reproductive study of Cassia occidentalis L. in female Wistar rats</title><title>Journal of ethnopharmacology</title><addtitle>J Ethnopharmacol</addtitle><description>Cassia occidentalis L. (Leguminosae) has long been used as natural medicine in rainforests and other tropical regions for the treatment of inflammation, fever, liver disorders, constipation, worms, fungal infections, ulcers, respiratory infections, snakebite and as a potent abortifacient.
This study has investigated the effects of oral sub-acute administration of
Cassia occidentalis during pregnancy in female Wistar rats.
Three groups of pregnant rats were treated orally from the 1st to the 6th day (pre-implantation period) and from the 7th to the 14th day (organogenic period) of pregnancy, with doses of 250 and 500
mg/kg. On the 20th day of pregnancy, the animals were euthanized and reproductive parameters evaluated.
The results revealed no statistically significant differences between the control and treated groups in terms of offspring/dam relationship; fetuses, placentae and ovaries weights; number of implantation and resorption sites; number of corpora lutea in the ovaries and pre- and post-implantation loss rates. However, the presence of dead fetuses was registered in both doses of 250 and 500
mg/kg of
Cassia occidentalis.
Further studies should therefore be conducted to obtain more detailed characteristics of the toxic effects of this species, the use of which is not recommended during pregnancy.</description><subject>adverse effects</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cassia occidentalis</subject><subject>Cassia occidentalis L</subject><subject>corpus luteum</subject><subject>Dose-Response Relationship, Drug</subject><subject>embryo implantation</subject><subject>Fabaceae</subject><subject>Fedegoso</subject><subject>Female</subject><subject>females</subject><subject>Fetal Death</subject><subject>fetus</subject><subject>General pharmacology</subject><subject>genotoxicity</subject><subject>Leguminosae</subject><subject>litter size</subject><subject>Medical sciences</subject><subject>medicinal plants</subject><subject>medicinal properties</subject><subject>mutagenicity</subject><subject>oral administration</subject><subject>organogenesis</subject><subject>ovaries</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>placenta</subject><subject>Plant Extracts - toxicity</subject><subject>Pregnancy</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Reproduction - drug effects</subject><subject>reproductive toxicology</subject><subject>Senna occidentalis</subject><subject>Senna Plant - chemistry</subject><subject>subacute toxicity</subject><subject>temporal variation</subject><subject>tissue weight</subject><subject>Toxicology</subject><issn>0378-8741</issn><issn>1872-7573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><recordid>eNqN0E2LFDEQgOEgijuu_gAvmoveuk2lP5LGkwx-wYCCu3gM1UllydDTGZPuxf33Zp1Bb-IplydVxcvYcxA1COjf7Os9HWsphK4BatGIB2wDWslKdap5yDaiUbrSqoUL9iTnvRBCQSseswsYWjk0Xb9hX6_iz2DjFG-CxYknOqboVruEW-J5Wd0dj55vMeeAPFobHM0LTiHzXc3DzD0dcCL-PeQFE0-45Kfskccp07Pze8muP7y_2n6qdl8-ft6-21W27dVSjQTWaU9WN6hbrTvvR69bib0D7_XoZdsNDiQOSnrrOiSLshej0u04eDk2l-z1aW45-MdKeTGHkC1NE84U12yk6Aeluv6_YN81okA4QZtizom8OaZwwHRnQJj73mZvSm9z39sAGPH7z4vz8HU8kPv74xy4gFdngLkE9glnG_IfJ6Etu6Ep7uXJeYwGb1Ix19-kgKbslVIKVcTbk6BS9TZQMtkGmi25kMguxsXwj0N_Ab15p2g</recordid><startdate>20090504</startdate><enddate>20090504</enddate><creator>Aragão, T.P.</creator><creator>Lyra, M.M.A.</creator><creator>Silva, M.G.B.</creator><creator>Andrade, B.A.</creator><creator>Ferreira, P.A.</creator><creator>Ortega, L.F.</creator><creator>da Silva, S.D.</creator><creator>da Silva, J.C.P.</creator><creator>Fraga, M.C.C.A.</creator><creator>Wanderley, A.G.</creator><creator>Lafayette, S.S.L.</creator><general>Elsevier Ireland Ltd</general><general>Amsterdam; New York: Elsevier</general><general>Elsevier</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope><scope>M7N</scope></search><sort><creationdate>20090504</creationdate><title>Toxicological reproductive study of Cassia occidentalis L. in female Wistar rats</title><author>Aragão, T.P. ; Lyra, M.M.A. ; Silva, M.G.B. ; Andrade, B.A. ; Ferreira, P.A. ; Ortega, L.F. ; da Silva, S.D. ; da Silva, J.C.P. ; Fraga, M.C.C.A. ; Wanderley, A.G. ; Lafayette, S.S.L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c467t-be1cd8fec83a84885ffbf842a6d1ff8bf2459d12a972fcd5aeca260b784b9f2b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>adverse effects</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cassia occidentalis</topic><topic>Cassia occidentalis L</topic><topic>corpus luteum</topic><topic>Dose-Response Relationship, Drug</topic><topic>embryo implantation</topic><topic>Fabaceae</topic><topic>Fedegoso</topic><topic>Female</topic><topic>females</topic><topic>Fetal Death</topic><topic>fetus</topic><topic>General pharmacology</topic><topic>genotoxicity</topic><topic>Leguminosae</topic><topic>litter size</topic><topic>Medical sciences</topic><topic>medicinal plants</topic><topic>medicinal properties</topic><topic>mutagenicity</topic><topic>oral administration</topic><topic>organogenesis</topic><topic>ovaries</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>placenta</topic><topic>Plant Extracts - toxicity</topic><topic>Pregnancy</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Reproduction - drug effects</topic><topic>reproductive toxicology</topic><topic>Senna occidentalis</topic><topic>Senna Plant - chemistry</topic><topic>subacute toxicity</topic><topic>temporal variation</topic><topic>tissue weight</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Aragão, T.P.</creatorcontrib><creatorcontrib>Lyra, M.M.A.</creatorcontrib><creatorcontrib>Silva, M.G.B.</creatorcontrib><creatorcontrib>Andrade, B.A.</creatorcontrib><creatorcontrib>Ferreira, P.A.</creatorcontrib><creatorcontrib>Ortega, L.F.</creatorcontrib><creatorcontrib>da Silva, S.D.</creatorcontrib><creatorcontrib>da Silva, J.C.P.</creatorcontrib><creatorcontrib>Fraga, M.C.C.A.</creatorcontrib><creatorcontrib>Wanderley, A.G.</creatorcontrib><creatorcontrib>Lafayette, S.S.L.</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><jtitle>Journal of ethnopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Aragão, T.P.</au><au>Lyra, M.M.A.</au><au>Silva, M.G.B.</au><au>Andrade, B.A.</au><au>Ferreira, P.A.</au><au>Ortega, L.F.</au><au>da Silva, S.D.</au><au>da Silva, J.C.P.</au><au>Fraga, M.C.C.A.</au><au>Wanderley, A.G.</au><au>Lafayette, S.S.L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Toxicological reproductive study of Cassia occidentalis L. in female Wistar rats</atitle><jtitle>Journal of ethnopharmacology</jtitle><addtitle>J Ethnopharmacol</addtitle><date>2009-05-04</date><risdate>2009</risdate><volume>123</volume><issue>1</issue><spage>163</spage><epage>166</epage><pages>163-166</pages><issn>0378-8741</issn><eissn>1872-7573</eissn><coden>JOETD7</coden><abstract>Cassia occidentalis L. (Leguminosae) has long been used as natural medicine in rainforests and other tropical regions for the treatment of inflammation, fever, liver disorders, constipation, worms, fungal infections, ulcers, respiratory infections, snakebite and as a potent abortifacient.
This study has investigated the effects of oral sub-acute administration of
Cassia occidentalis during pregnancy in female Wistar rats.
Three groups of pregnant rats were treated orally from the 1st to the 6th day (pre-implantation period) and from the 7th to the 14th day (organogenic period) of pregnancy, with doses of 250 and 500
mg/kg. On the 20th day of pregnancy, the animals were euthanized and reproductive parameters evaluated.
The results revealed no statistically significant differences between the control and treated groups in terms of offspring/dam relationship; fetuses, placentae and ovaries weights; number of implantation and resorption sites; number of corpora lutea in the ovaries and pre- and post-implantation loss rates. However, the presence of dead fetuses was registered in both doses of 250 and 500
mg/kg of
Cassia occidentalis.
Further studies should therefore be conducted to obtain more detailed characteristics of the toxic effects of this species, the use of which is not recommended during pregnancy.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>19429356</pmid><doi>10.1016/j.jep.2008.11.030</doi><tpages>4</tpages></addata></record> |
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| ispartof | Journal of ethnopharmacology, 2009-05, Vol.123 (1), p.163-166 |
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| subjects | adverse effects Animals Biological and medical sciences Cassia occidentalis Cassia occidentalis L corpus luteum Dose-Response Relationship, Drug embryo implantation Fabaceae Fedegoso Female females Fetal Death fetus General pharmacology genotoxicity Leguminosae litter size Medical sciences medicinal plants medicinal properties mutagenicity oral administration organogenesis ovaries Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments placenta Plant Extracts - toxicity Pregnancy Rats Rats, Wistar Reproduction - drug effects reproductive toxicology Senna occidentalis Senna Plant - chemistry subacute toxicity temporal variation tissue weight Toxicology |
| title | Toxicological reproductive study of Cassia occidentalis L. in female Wistar rats |
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