Lactobacillus acidophilus ameliorates pain and cartilage degradation in experimental osteoarthritis

•L. acidophilus improves MIA-induced OA development through downregulation of pain severity and cartilage damage.•L. acidophilus decreases the expression of proinflammatory cytokines but promotes anti-inflammatory cyotokines production in joint.•L. acidophilus regulates a reciprocal balance between...

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Bibliographic Details
Published in:Immunology letters 2018-11, Vol.203, p.6-14
Main Authors: Lee, Seung Hoon, Kwon, Ji Ye, Jhun, JooYeon, Jung, KyungAh, Park, Sung-Hwan, Yang, Chul Woo, Cho, YongSin, Kim, Seok Jung, Cho, Mi-La
Format: Article
Language:English
Subjects:
Animals
Cartilage
Cartilage - immunology
Cartilage - pathology
Chondrocytes - immunology
Chondrocytes - pathology
Iodoacetic Acid - toxicity
Lactobacillus acidophilus
Male
Osteoarthritis
Osteoarthritis - chemically induced
Osteoarthritis - immunology
Osteoarthritis - pathology
Osteoarthritis - therapy
Pain - chemically induced
Pain - immunology
Pain - pathology
Pain Management
Rats, Wistar
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Summary:•L. acidophilus improves MIA-induced OA development through downregulation of pain severity and cartilage damage.•L. acidophilus decreases the expression of proinflammatory cytokines but promotes anti-inflammatory cyotokines production in joint.•L. acidophilus regulates a reciprocal balance between anabolic and catabolic factors in OA chondrocytes. Osteoarthritis (OA) is a chronic and degenerative disease that causes pain, cartilage deformation, and joint inflammation. Lactobacillus species have been used as dietary supplements to induce the production of antimicrobial and anti-inflammatory factors. The goal of this study was to determine whether Lactobacillus acidophilus ameliorates monosodium iodoacetate-induced OA. L. acidophilus showed anti-nociceptive properties and protected against cartilage destruction. It also downregulated the levels of proinflammatory cytokines and increased the levels of anti-inflammatory cytokines in the joints of OA rats. L. acidophilus additionally restored the balance between anabolic and catabolic factors in chondrocytes from OA patients. These results suggest that L. acidophilus can alleviate OA-associated pain and delay the progression of the disease by inhibiting proinflammatory cytokine production and reducing cartilage damage.
ISSN:0165-2478
1879-0542
DOI:10.1016/j.imlet.2018.07.003