Evaluation of the Possibility of Correction of Doxorubicin-Induced Chronic Heart Failure in the Experiment with 3-Hydroxypyridine Acetylcysteinate and 3-Hydroxypyridine Succinate

The possibility of correction of morphological changes in the myocardium and biochemical parameters of the blood with 3-hydroxypyridine acetylcysteinate in a dose of 25 mg/kg was studied in the model of doxorubicin-induced chronic heart failure in rats. It was found that 3-hydroxypyridine acetylcyst...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2018-07, Vol.165 (3), p.344-346
Main Authors: Zamotaeva, M. N., Inchina, V. I., Konorev, V. V., Kuznetsov, Yu. V., Kuz’michev, N. D.
Format: Article
Language:English
Subjects:
Anthracyclines
Beta blockers
Biomedical and Life Sciences
Biomedicine
Cell Biology
Development and progression
Doxorubicin
Heart diseases
Heart failure
Internal Medicine
Laboratory Medicine
Membrane lipids
Membrane proteins
Myocardium
Pathology
Type 2 diabetes
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Summary:The possibility of correction of morphological changes in the myocardium and biochemical parameters of the blood with 3-hydroxypyridine acetylcysteinate in a dose of 25 mg/kg was studied in the model of doxorubicin-induced chronic heart failure in rats. It was found that 3-hydroxypyridine acetylcysteinate in a dose of 25 mg/kg produced less pronounced cardio-protective effect in experimental chronic heart failure than 3-hydroxypyridine succinate.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-018-4166-y