Effects of Glycolipid Rhodococcus Biosurfactant on Innate and Adaptive Immunity Parameters In Vivo

The glycolipid biosurfactant complex from actinobacterium Rhodococcus ruber IEGM 231 inhibits the innate and adaptive immunity parameters after intraperitoneal and intramuscular injection. Marked suppression of antibody production, bactericidal potential, and production of proinflammatory cytokines...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2018-07, Vol.165 (3), p.368-372
Main Authors: Gein, S. V., Kochina, O. A., Kuyukina, M. S., Ivshina, I. B.
Format: Article
Language:English
Subjects:
Adaptive immunity
Analysis
Antibodies
Antiviral agents
Biomedical and Life Sciences
Biomedicine
Biosurfactants
Cell Biology
Cytokines
Glycolipids
Immune response
Immunity (Disease)
Immunology and Microbiology
Immunostimulation
Inflammation
Internal Medicine
Laboratory Medicine
Macrophages
Membrane lipids
Pathology
Peritoneum
Surfactants
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Description
Summary:The glycolipid biosurfactant complex from actinobacterium Rhodococcus ruber IEGM 231 inhibits the innate and adaptive immunity parameters after intraperitoneal and intramuscular injection. Marked suppression of antibody production, bactericidal potential, and production of proinflammatory cytokines by peritoneal macrophages, detected in vivo , do not agree with the previously detected immunostimulatory activity of biosurfactants towards the immunocompetent cell cultures; this fact indicates an important role of the cell environment in the formation of immune response under the effect of bacterial glycolipids.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-018-4172-0