Dynamics of Changes in Metabolic and Hematological Parameters after Transplantation of Pancreatic Islet Cells on TiNi Scaffold in Experimental Diabetes Mellitus

The dynamics of the development of the pancreatic islet cells in the porous TiNi scaffold was studied by electron microscopy. Changes in the metabolism of glucose and glycosylated hemoglobin and parameters of the peripheral blood and bone marrow were shown after transplantation of pancreatic islet c...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2018-07, Vol.165 (3), p.394-398
Main Authors: Kokorev, O. V., Khodorenko, V. N., Anikeev, S. G., Gunter, V. E.
Format: Article
Language:English
Subjects:
Analysis
Biomedical and Life Sciences
Biomedicine
Biotechnologies
Bone marrow transplantation
Cell Biology
Diabetes
Diabetes mellitus
Electron microscopy
Glucose metabolism
Glycosylated hemoglobin
Hemoglobin
Hemopoiesis
Internal Medicine
Islet cells
Laboratory Medicine
Pancreas transplantation
Pancreatic islet transplantation
Pathology
Peripheral blood
T cell receptors
Tissue engineering
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Summary:The dynamics of the development of the pancreatic islet cells in the porous TiNi scaffold was studied by electron microscopy. Changes in the metabolism of glucose and glycosylated hemoglobin and parameters of the peripheral blood and bone marrow were shown after transplantation of pancreatic islet cells on porous permeable TiNi scaffold during alloxan-induced diabetes. The cells administered on the porous biocompatible scaffold produced more prolonged anti-diabetic effect and normalized hemopoiesis parameters in comparison with their intraperitoneal administration. The experiment on pancreatic islet cells showed that porous permeable TiNi scaffold is a unique cell incubator acceptable for usage for tissue engineering.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-018-4178-7