Bone Disease and Idiopathic Hypercalciuria

There is sufficient epidemiological and clinical data demonstrating an association between reduced bone mineral density and idiopathic hypercalciuria (IH). There have been relatively few studies that have addressed the underlying defect in bone remodeling. The limited studies to date suggest that in...

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Bibliographic Details
Published in:Clinical reviews in bone and mineral metabolism 2008-12, Vol.6 (3-4), p.82-94
Main Author: Zerwekh, Joseph E.
Format: Article
Language:English
Subjects:
Endocrinology
Gynecology
Internal Medicine
Medicine
Medicine & Public Health
Original Paper
Orthopedics
Rheumatology
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Summary:There is sufficient epidemiological and clinical data demonstrating an association between reduced bone mineral density and idiopathic hypercalciuria (IH). There have been relatively few studies that have addressed the underlying defect in bone remodeling. The limited studies to date suggest that increased bone turnover occurs in some forms of IH such as fasting hypercalciuria or renal calcium leak and explains the bone loss observed in these forms of IH. On the other hand, defective bone formation is the major defect observed in patients with IH resulting from intestinal hyperabsorption of calcium. These alterations in bone remodeling have been ascribed to genetic, metabolic, and nutritional causes. Although there are several therapeutic options available for treating such patients and preventing stone recurrence, prevention of future bone loss should also be considered to prevent the increased risk of osteoporotic fracture in patients with IH.
ISSN:1534-8644
1559-0119
DOI:10.1007/s12018-008-9023-5