Preparation and characterization of dialdehyde β-cyclodextrin with broad-spectrum antibacterial activity

• Published in: Food research international 2018-09, Vol.111, p.237-243
• Main Authors: Ren, He, Lyu, Yongbo, Li, Xinying, Zhang, Shuxiao, Ye, Yusong, Li, Defu, Mu, Changdao
• Format: Article
• Language: English
• Subjects: Antibacterial activity; Aqueous solubility; Dialdehyde β-cyclodextrin; Periodate oxidation
• ISSN: 0963-9969; 1873-7145
• DOI: 10.1016/j.foodres.2018.05.039

Consumers demand more alternatives of riskless antibacterial agents to prevent microbial contamination in food industry. Oxidized carbohydrate may be a potential option as new antibacterial agent. However, the relatively weak antibacterial property of oxidized carbohydrate is not satisfactory. In this paper, dialdehyde β-cyclodextrins with different oxidation degree were prepared by periodate oxidation and their antibacterial properties were systematically studied. The results showed that multi-aldehyde groups were successfully introduced into β-cyclodextrin molecules by periodate oxidation. The aqueous solubility and stability of dialdehyde β-cyclodextrins were improved as expected. It is interesting that dialdehyde β-cyclodextrins possessed outstanding antibacterial activity against both Gram-positive and Gram-negative bacteria. The minimal inhibitory concentrations against E. coli, S. aureus and B. subtilis reached 0.63, 1.25 and 0.63 mg/mL, respectively. Moreover, dialdehyde β-cyclodextrins effectively inhibited bacterial growth on the surface of apples. The results demonstrated that oxidized oligosaccharide with multi-aldehyde groups and good dispersibility in aqueous solution possessed satisfactory antibacterial activity, which can be used as new antibacterial agent in food industry. [Display omitted] •Dialdehyde β-cyclodextrins with different oxidation degree were synthesized.•Aqueous dispersibility of β-cyclodextrin was highly improved by oxidation.•Dialdehyde β-cyclodextrin possessed outstanding antibacterial activity.•Dialdehyde β-cyclodextrin could effectively extend the storage time of apple.•Dialdehyde β-cyclodextrin could be used as new antibacterial agent in food industry.