[18F]-Fluorodeoxyglucose PET/CT imaging as a marker of carotid plaque inflammation: Comparison to immunohistology and relationship to acuity of events

[18F]-fluorodeoxyglucose (18FDG) uptake imaged with positron emission tomography (PET) and computed tomography (CT) may serve as a biomarker of plaque inflammation. This study evaluated the relationship between carotid plaque 18FDG uptake and a) intraplaque expression of macrophage and macrophage-li...

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Bibliographic Details
Published in:International journal of cardiology 2018-11, Vol.271, p.378-386
Main Authors: Cocker, Myra S., Spence, J. David, Hammond, Robert, deKemp, Robert A., Lum, Cheemun, Wells, George, Bernick, Jordan, Hill, Andrew, Nagpal, Sudhir, Stotts, Grant, Alturkustani, Murad, Adeeko, Adebayo, Yerofeyeva, Yulia, Rayner, Katey, Peterson, Joan, Khan, Ali R., Naidas, Ann C., Garrard, Linda, Yaffe, Martin J., Leung, Eugene, Prato, Frank S., Tardif, Jean-Claude, Beanlands, Rob S.B.
Format: Article
Language:English
Subjects:
18FDG PET/CT
[18-F]-fluorodeoxyglucose
Acuity
Aged
Carotid plaque inflammation
Carotid Stenosis - diagnostic imaging
Carotid Stenosis - metabolism
Carotid Stenosis - surgery
Cohort Studies
Endarterectomy, Carotid - methods
Female
Fluorodeoxyglucose F18 - metabolism
Humans
Leukocyte
Macrophage
Male
Middle Aged
Plaque, Atherosclerotic - diagnostic imaging
Plaque, Atherosclerotic - metabolism
Plaque, Atherosclerotic - surgery
Positron Emission Tomography Computed Tomography - methods
Prospective Studies
Symptoms
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Summary:[18F]-fluorodeoxyglucose (18FDG) uptake imaged with positron emission tomography (PET) and computed tomography (CT) may serve as a biomarker of plaque inflammation. This study evaluated the relationship between carotid plaque 18FDG uptake and a) intraplaque expression of macrophage and macrophage-like cellular CD68 immunohistology; b) intraplaque inflammatory burden using leukocyte-sensitive CD45 immunohistology; c) symptomatic patient presentation; d) time from last cerebrovascular event. 54 patients scheduled for carotid endarterectomy underwent 18FDG PET/CT imaging. Maximum 18FDG uptake (SUVmax) and tissue-to-blood ratio (TBRmax) was measured for carotid plaques. Quantitative immunohistological analysis of macrophage-like cell expression (CD68) and leukocyte content (CD45) was performed. 18FDG uptake was related to CD68 macrophage expression (TBRmax: r = 0.51, p 
ISSN:0167-5273
1874-1754
DOI:10.1016/j.ijcard.2018.05.057