Consequence of Elevated Fibroblast Growth Factor 23 Levels in Acute Kidney Injury, Renal Recovery and Overall Survival in Intensive Care Unit Patients After Major Surgery

The main goal of our study was to investigate the role of increased fibroblast growth factor 23 (FGF23) levels on renal recovery and overall survival. We conducted a prospective case‐control cohort study, which included 121 adult cases who developed AKI after major surgical procedures. The subjects...

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Bibliographic Details
Published in:Therapeutic apheresis and dialysis 2018-10, Vol.22 (5), p.544-551
Main Authors: Sakan, Sanja, Premuzic, Vedran, Bandic Pavlovic, Daniela, Basic‐Jukic, Nikolina
Format: Article
Language:English
Subjects:
Acute kidney injury
Acute Kidney Injury - blood
Acute Kidney Injury - mortality
Acute Kidney Injury - physiopathology
Case-Control Studies
Cohort Studies
Creatinine - blood
Female
Fibroblast growth factor 23
Fibroblast Growth Factors - blood
Follow-Up Studies
Humans
Intensive Care Units
Male
Middle Aged
Mortality
Postoperative Complications - epidemiology
Predictive Value of Tests
Prognosis
Prospective Studies
Risk Factors
Severity of Illness Index
Survival Rate
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Summary:The main goal of our study was to investigate the role of increased fibroblast growth factor 23 (FGF23) levels on renal recovery and overall survival. We conducted a prospective case‐control cohort study, which included 121 adult cases who developed AKI after major surgical procedures. The subjects were followed‐up until the last enrolled patient survived 180 days or until the time of death. Higher FGF23 levels positively correlated with serum creatinine levels (P
ISSN:1744-9979
1744-9987
DOI:10.1111/1744-9987.12703