Caloric restriction can affect one-carbon metabolism during pregnancy in the rat: A transgenerational model

One-carbon metabolism is critical to pregnancy outcomes, because it determines the availability of nutrients involved in cell divisions and DNA methylation. The aim of this study was to analyze how 50% prenatal calorie restriction affected one-carbon metabolism in pregnant Wistar rats of the F0 to F...

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Bibliographic Details
Published in:Biochimie 2018-09, Vol.152, p.181-187
Main Authors: Chmurzynska, A., Mlodzik, M.A., Radziejewska, A., Szwengiel, A., Malinowska, A.M., Nowacka-Woszuk, J.
Format: Article
Language:English
Subjects:
Choline
Fetal programming
Gene expression
Homocysteine
Pregnancy
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Summary:One-carbon metabolism is critical to pregnancy outcomes, because it determines the availability of nutrients involved in cell divisions and DNA methylation. The aim of this study was to analyze how 50% prenatal calorie restriction affected one-carbon metabolism in pregnant Wistar rats of the F0 to F2 generations. Mean choline (p 
ISSN:0300-9084
1638-6183
DOI:10.1016/j.biochi.2018.07.007