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Caloric restriction can affect one-carbon metabolism during pregnancy in the rat: A transgenerational model
One-carbon metabolism is critical to pregnancy outcomes, because it determines the availability of nutrients involved in cell divisions and DNA methylation. The aim of this study was to analyze how 50% prenatal calorie restriction affected one-carbon metabolism in pregnant Wistar rats of the F0 to F...
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| Published in: | Biochimie 2018-09, Vol.152, p.181-187 |
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| container_title | Biochimie |
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| creator | Chmurzynska, A. Mlodzik, M.A. Radziejewska, A. Szwengiel, A. Malinowska, A.M. Nowacka-Woszuk, J. |
| description | One-carbon metabolism is critical to pregnancy outcomes, because it determines the availability of nutrients involved in cell divisions and DNA methylation. The aim of this study was to analyze how 50% prenatal calorie restriction affected one-carbon metabolism in pregnant Wistar rats of the F0 to F2 generations. Mean choline (p |
| doi_str_mv | 10.1016/j.biochi.2018.07.007 |
| format | article |
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•Food deprivation leads to lowered choline, betaine, and S-adenosylmethionine concentrations in pregnant rats.•Calorie restriction in F0 dams does not stimulate changes in one-carbon metabolism that can be observed in their offspring during pregnancy.•Calorie restriction in the F0 dams leads to moderate changes in Mat1a, Bhmt, Cbs, Pemt, and Mthfr gene expression in their F1-F2 offspring.]]></description><identifier>ISSN: 0300-9084</identifier><identifier>EISSN: 1638-6183</identifier><identifier>DOI: 10.1016/j.biochi.2018.07.007</identifier><identifier>PMID: 30009859</identifier><language>eng</language><publisher>France: Elsevier B.V</publisher><subject>Choline ; Fetal programming ; Gene expression ; Homocysteine ; Pregnancy</subject><ispartof>Biochimie, 2018-09, Vol.152, p.181-187</ispartof><rights>2018 Elsevier B.V. and Société Française de Biochimie et Biologie Moléculaire (SFBBM)</rights><rights>Copyright © 2018 Elsevier B.V. and Société Française de Biochimie et Biologie Moléculaire (SFBBM). All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c362t-fa8228784ad7975bf3fbe38c43093f535db4cb38d28434a60914b482f4a8f5983</citedby><cites>FETCH-LOGICAL-c362t-fa8228784ad7975bf3fbe38c43093f535db4cb38d28434a60914b482f4a8f5983</cites><orcidid>0000-0002-2045-0709</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30009859$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chmurzynska, A.</creatorcontrib><creatorcontrib>Mlodzik, M.A.</creatorcontrib><creatorcontrib>Radziejewska, A.</creatorcontrib><creatorcontrib>Szwengiel, A.</creatorcontrib><creatorcontrib>Malinowska, A.M.</creatorcontrib><creatorcontrib>Nowacka-Woszuk, J.</creatorcontrib><title>Caloric restriction can affect one-carbon metabolism during pregnancy in the rat: A transgenerational model</title><title>Biochimie</title><addtitle>Biochimie</addtitle><description><![CDATA[One-carbon metabolism is critical to pregnancy outcomes, because it determines the availability of nutrients involved in cell divisions and DNA methylation. The aim of this study was to analyze how 50% prenatal calorie restriction affected one-carbon metabolism in pregnant Wistar rats of the F0 to F2 generations. Mean choline (p < 0.001), betaine (p < 0.001), and S-adenosylmethionine (SAM) (p < 0.05) concentrations were respectively about 40%, 45%, and 20% lower in the F0_R (R – restricted diet) than in the F0_C (C – control diet). Homocysteine, S-adenosylhomocysteine (SAH), and trimethylamine oxide concentrations were unaffected. In the F1_R, the SAM-to-SAH ratio was 25% higher (p < 0.05) than in the F1_C. No differences between the C and R groups were observed in the F2 generation. The SAM concentrations in the F1_R were higher than in the F0_R and the F2_R (p < 0.01). The relative transcript levels of Mat1a, Bhmt, Cbs, Pemt, and Mthfr were only slightly affected by the diet, with changes of less than a factor of 2.0. Cbs activity in the F2_R was significantly higher than in the F2_C (p < 0.001). Food deprivation may affect one-carbon metabolism in pregnant rats, but it does not stimulate persistent metabolic changes that can be observed during the pregnancy of their progeny of the F1 or F2 generations.
•Food deprivation leads to lowered choline, betaine, and S-adenosylmethionine concentrations in pregnant rats.•Calorie restriction in F0 dams does not stimulate changes in one-carbon metabolism that can be observed in their offspring during pregnancy.•Calorie restriction in the F0 dams leads to moderate changes in Mat1a, Bhmt, Cbs, Pemt, and Mthfr gene expression in their F1-F2 offspring.]]></description><subject>Choline</subject><subject>Fetal programming</subject><subject>Gene expression</subject><subject>Homocysteine</subject><subject>Pregnancy</subject><issn>0300-9084</issn><issn>1638-6183</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp9kE9r3DAQxUVpaDZpv0EpOvZiZ2zJttRDISz5B4FckrOQ5NGutra0lbyFfPsq7KbHnh4zvDfD-xHytYG6gaa_2tXGR7v1dQuNqGGoAYYPZNX0TFR9I9hHsgIGUEkQ_Jxc5LwDgA5a-Ymclz1I0ckV-bXWU0ze0oR5Kbr4GKjVgWrn0C40BqysTqZsZ1y0iZPPMx0PyYcN3SfcBB3sK_WBLlukSS8_6DVdkg55gwHLXO7pic5xxOkzOXN6yvjlpJfk5fbmeX1fPT7dPayvHyvL-napnBZtKwbB9TjIoTOOOYNMWM5AMtexbjTcGibGVnDGdQ-y4YaL1nEtXCcFuyTfj3f3Kf4-lF5q9tniNOmA8ZBVCwMIYL0cipUfrTbFnBM6tU9-1ulVNaDeMKudOmJWb5gVDKpgLrFvpw8HM-P4L_TOtRh-Hg1Yev7xmFS2HoPF0aeCVY3R___DXxzwkNI</recordid><startdate>201809</startdate><enddate>201809</enddate><creator>Chmurzynska, A.</creator><creator>Mlodzik, M.A.</creator><creator>Radziejewska, A.</creator><creator>Szwengiel, A.</creator><creator>Malinowska, A.M.</creator><creator>Nowacka-Woszuk, J.</creator><general>Elsevier B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-2045-0709</orcidid></search><sort><creationdate>201809</creationdate><title>Caloric restriction can affect one-carbon metabolism during pregnancy in the rat: A transgenerational model</title><author>Chmurzynska, A. ; Mlodzik, M.A. ; Radziejewska, A. ; Szwengiel, A. ; Malinowska, A.M. ; Nowacka-Woszuk, J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c362t-fa8228784ad7975bf3fbe38c43093f535db4cb38d28434a60914b482f4a8f5983</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Choline</topic><topic>Fetal programming</topic><topic>Gene expression</topic><topic>Homocysteine</topic><topic>Pregnancy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chmurzynska, A.</creatorcontrib><creatorcontrib>Mlodzik, M.A.</creatorcontrib><creatorcontrib>Radziejewska, A.</creatorcontrib><creatorcontrib>Szwengiel, A.</creatorcontrib><creatorcontrib>Malinowska, A.M.</creatorcontrib><creatorcontrib>Nowacka-Woszuk, J.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biochimie</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chmurzynska, A.</au><au>Mlodzik, M.A.</au><au>Radziejewska, A.</au><au>Szwengiel, A.</au><au>Malinowska, A.M.</au><au>Nowacka-Woszuk, J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Caloric restriction can affect one-carbon metabolism during pregnancy in the rat: A transgenerational model</atitle><jtitle>Biochimie</jtitle><addtitle>Biochimie</addtitle><date>2018-09</date><risdate>2018</risdate><volume>152</volume><spage>181</spage><epage>187</epage><pages>181-187</pages><issn>0300-9084</issn><eissn>1638-6183</eissn><abstract><![CDATA[One-carbon metabolism is critical to pregnancy outcomes, because it determines the availability of nutrients involved in cell divisions and DNA methylation. The aim of this study was to analyze how 50% prenatal calorie restriction affected one-carbon metabolism in pregnant Wistar rats of the F0 to F2 generations. Mean choline (p < 0.001), betaine (p < 0.001), and S-adenosylmethionine (SAM) (p < 0.05) concentrations were respectively about 40%, 45%, and 20% lower in the F0_R (R – restricted diet) than in the F0_C (C – control diet). Homocysteine, S-adenosylhomocysteine (SAH), and trimethylamine oxide concentrations were unaffected. In the F1_R, the SAM-to-SAH ratio was 25% higher (p < 0.05) than in the F1_C. No differences between the C and R groups were observed in the F2 generation. The SAM concentrations in the F1_R were higher than in the F0_R and the F2_R (p < 0.01). The relative transcript levels of Mat1a, Bhmt, Cbs, Pemt, and Mthfr were only slightly affected by the diet, with changes of less than a factor of 2.0. Cbs activity in the F2_R was significantly higher than in the F2_C (p < 0.001). Food deprivation may affect one-carbon metabolism in pregnant rats, but it does not stimulate persistent metabolic changes that can be observed during the pregnancy of their progeny of the F1 or F2 generations.
•Food deprivation leads to lowered choline, betaine, and S-adenosylmethionine concentrations in pregnant rats.•Calorie restriction in F0 dams does not stimulate changes in one-carbon metabolism that can be observed in their offspring during pregnancy.•Calorie restriction in the F0 dams leads to moderate changes in Mat1a, Bhmt, Cbs, Pemt, and Mthfr gene expression in their F1-F2 offspring.]]></abstract><cop>France</cop><pub>Elsevier B.V</pub><pmid>30009859</pmid><doi>10.1016/j.biochi.2018.07.007</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-2045-0709</orcidid></addata></record> |
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| subjects | Choline Fetal programming Gene expression Homocysteine Pregnancy |
| title | Caloric restriction can affect one-carbon metabolism during pregnancy in the rat: A transgenerational model |
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