Haptoglobin-Hemoglobin Receptor Conveys Innate Immunity to Trypanosoma brucei in Humans

The protozoan parasite Trypanosoma brucei is lysed by apolipoprotein L-I, a component of human high-density lipoprotein (HDL) particles that are also characterized by the presence of haptoglobin-related protein. We report that this process is mediated by a parasite glycoprotein receptor, which binds...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 2008-05, Vol.320 (5876), p.677-681
Main Authors: Vanhollebeke, Benoit, De Muylder, Géraldine, Nielsen, Marianne J, Pays, Annette, Tebabi, Patricia, Dieu, Marc, Raes, Martine, Moestrup, Soren K, Pays, Etienne
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Animals
Biological and medical sciences
Blood
Cell receptors
Cell structures and functions
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Genetics of the immune response
Haptoglobins - metabolism
HDL lipoproteins
Hemoglobins
Hemoglobins - metabolism
Humans
Immunity (Disease)
Immunity, Innate
Immunobiology
Immunology
Innate immunity
Lipoproteins, HDL - metabolism
Macrophages
Mice
Mice, Inbred Strains
Miscellaneous
Molecular and cellular biology
Molecular Sequence Data
Parasite hosts
Parasites
Parasitology
Proteins
Receptors
Receptors, Cell Surface - immunology
Receptors, Cell Surface - metabolism
Trypanosoma brucei
Trypanosoma brucei brucei - immunology
Trypanosome
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Summary:The protozoan parasite Trypanosoma brucei is lysed by apolipoprotein L-I, a component of human high-density lipoprotein (HDL) particles that are also characterized by the presence of haptoglobin-related protein. We report that this process is mediated by a parasite glycoprotein receptor, which binds the haptoglobin-hemoglobin complex with high affinity for the uptake and incorporation of heme into intracellular hemoproteins. In mice, this receptor was required for optimal parasite growth and the resistance of parasites to the oxidative burst by host macrophages. In humans, the trypanosome receptor also recognized the complex between hemoglobin and haptoglobin-related protein, which explains its ability to capture trypanolytic HDLs. Thus, in humans the presence of haptoglobin-related protein has diverted the function of the trypanosome haptoglobin-hemoglobin receptor to elicit innate host immunity against the parasite.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.1156296