Autocrine actions of macrophage-derived catecholamines on interleukin-1 sub( beta )

Previous studies indicate that norepinephrine and epinephrine modulate production of interleukin-1 sub( beta ) (IL-1 sub( beta )) by activated macrophages, but it is not known if macrophage-derived catecholamines affect IL-1 sub( beta ). In this study, recruited peritoneal macrophages from CBA/J fem...

Full description

Saved in:
Bibliographic Details
Published in:Journal of neuroimmunology 2005-03, Vol.160 (1-2), p.87-91
Main Authors: Engler, K L, Rudd, M L, Ryan, J J, Stewart, J K, Fischer-Stenger, K
Format: Article
Language:English
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Previous studies indicate that norepinephrine and epinephrine modulate production of interleukin-1 sub( beta ) (IL-1 sub( beta )) by activated macrophages, but it is not known if macrophage-derived catecholamines affect IL-1 sub( beta ). In this study, recruited peritoneal macrophages from CBA/J female mice were activated with lipopolysaccharide (LPS) and treated with vehicle or adrenergic receptor antagonists for 24 h. Extracellular and intracellular levels of IL-1 sub( beta ) were measured with ELISA. Treatment with the beta -adrenergic receptor antagonists propranolol or ICI 118,551 increased LPS-induced production of IL-1 sub( beta ), whereas treatment with the alpha -adrenergic antagonists phentolamine or yohimbine decreased IL-1 sub( beta ). These findings demonstrate that adrenergic receptor antagonists unmask autocrine actions of macrophage-derived catecholamines on IL-1 sub( beta ) that may influence the inflammatory response.
ISSN:0165-5728
DOI:10.1016/j.jneuroim.2004.11.005