Planar cell polarity in organ formation

The planar cell polarity (PCP) pathway controls a variety of morphological events across many species. During embryonic development, the PCP pathway regulates coordinated behaviour of groups of cells to direct morphogenetic processes such as convergent extension and collective cell migration. In thi...

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Bibliographic Details
Published in:Current opinion in cell biology 2018-12, Vol.55, p.96-103
Main Authors: Henderson, Deborah J, Long, David A, Dean, Charlotte H
Format: Article
Language:English
Subjects:
Animals
Cell Movement
Cell Polarity - genetics
Cytoskeleton - metabolism
Disease
Humans
Organ Specificity
Organogenesis
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Summary:The planar cell polarity (PCP) pathway controls a variety of morphological events across many species. During embryonic development, the PCP pathway regulates coordinated behaviour of groups of cells to direct morphogenetic processes such as convergent extension and collective cell migration. In this review we discuss the increasingly prominent role of the PCP pathway in organogenesis, focusing on the lungs, kidneys and heart. We also highlight emerging evidence that PCP gene mutations are associated with adult diseases.
ISSN:0955-0674
1879-0410
DOI:10.1016/j.ceb.2018.06.011