Dendriform pulmonary ossification leading to bilateral lung transplant: a case report

Metaplastic ossification within the lung is seen in a variety of diseases, usually as sequela of either a separate primary pulmonary parenchymal disease or an underlying cardiac disorder such as valvular disease. Primary intraalveolar ossification or ossification within the alveolar septa is a rare...

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Bibliographic Details
Published in:Virchows Archiv : an international journal of pathology 2018-09, Vol.473 (3), p.379-383
Main Authors: Carney, John M., Mammarappallil, Joseph G., Sporn, Thomas A., Pavlisko, Elizabeth N.
Format: Article
Language:English
Subjects:
Aged
Alveoli
Brief Report
Case reports
Coronary artery disease
Heart diseases
Humans
Lung - diagnostic imaging
Lung - pathology
Lung diseases
Lung Diseases - diagnostic imaging
Lung Diseases - pathology
Lung Diseases - surgery
Lung Transplantation
Male
Medicine
Medicine & Public Health
Ossification
Ossification, Heterotopic - diagnostic imaging
Ossification, Heterotopic - pathology
Ossification, Heterotopic - surgery
Pathology
Respiratory failure
Septum
Transplantation
Transplants & implants
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Summary:Metaplastic ossification within the lung is seen in a variety of diseases, usually as sequela of either a separate primary pulmonary parenchymal disease or an underlying cardiac disorder such as valvular disease. Primary intraalveolar ossification or ossification within the alveolar septa is a rare entity. Similarly, it is unusual to see overt, diffuse disease affecting the lung to the point of respiratory failure leading to lung transplant. We present a case of an adult male who underwent bilateral lung transplantation, with the native lung pathology showing diffuse, severe dendriform ossification of the bilateral upper and lower lung lobes. The gross and histologic findings along with the radiographic imaging are reviewed herein. Overall, primary ossification of the lung leading to lung transplant is a rare condition that pulmonologists caring for patients with interstitial lung disease should be aware of as a possible cause of the patient’s symptoms and lung dysfunction.
ISSN:0945-6317
1432-2307
DOI:10.1007/s00428-018-2412-3