Topical rapamycin (sirolimus) for the treatment of uncomplicated tufted angiomas in two children and review of the literature

The mTOR inhibitor rapamycin is used systemically for the treatment of vascular lesions. We report the first use of topical rapamycin for the successful treatment of two cases of tufted angioma. The evidence for the use of topical rapamycin in other dermatologic conditions is summarized to aid in cl...

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Bibliographic Details
Published in:Pediatric dermatology 2018-09, Vol.35 (5), p.e286-e290
Main Authors: Burleigh, Angela, Kanigsberg, Nordau, Lam, Joseph M.
Format: Article
Language:English
Subjects:
Case reports
Children
Clinical decision making
Decision making
Pediatrics
Rapamycin
sirolimus
TOR protein
Transdermal medication
tufted angioma
Tumors
Veins & arteries
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Summary:The mTOR inhibitor rapamycin is used systemically for the treatment of vascular lesions. We report the first use of topical rapamycin for the successful treatment of two cases of tufted angioma. The evidence for the use of topical rapamycin in other dermatologic conditions is summarized to aid in clinical decision making on preparations and anticipated side effects.
ISSN:0736-8046
1525-1470
DOI:10.1111/pde.13596