Characterization of upper airway obstruction using cine MRI in children with residual obstructive sleep apnea after adenotonsillectomy

• Published in: Sleep medicine 2018-10, Vol.50, p.79-86
• Main Authors: Isaiah, Amal, Kiss, Edgar, Olomu, Patrick, Koral, Korgun, Mitchell, Ron B.
• Format: Article
• Language: English
• Subjects: Adenotonsillectomy; Magnetic resonance imaging; Pediatric obstructive sleep apnea
• ISSN: 1389-9457; 1878-5506
• DOI: 10.1016/j.sleep.2017.10.006

Tonsillectomy and adenoidectomy (T&A) lead to resolution of obstructive sleep apnea (OSA) in most children. However, OSA persists in about 25–40% of children. Cinematic magnetic resonance imaging (cine MRI) can aid the management of persistent OSA by localizing airway obstruction. We describe our experience in implementing and optimizing a cine MRI protocol by using a 3 Tesla MRI scanner, and the use of dexmedetomidine for sedation to improve reproducibility, safety, and diagnostic accuracy. Patients aged 3–18 years who underwent cine MRI for the evaluation of persistent OSA after T&A and failed positive airway pressure (PAP) therapy were included. Clinical data and the apnea-hyponea index were compared with quantitative and qualitative estimates of airway obstruction from imaging sequences. A total of 36 children were included with a mean age of 9.6 ± 4.6 (SD) years with 40% over 12 years of age. Two-thirds of them were boys. Seventeen out of 36 children (47%) had Down syndrome. Single site and multilevel obstruction were identified in 21 of 36 patients (58%) and in 12 of 36 patients (33%), respectively. All cine MRIs were performed without complications. Multiple regression analysis demonstrated that a combination of the minimum airway diameter and body mass index z-score best predicted OSA severity (P = 0.002). Cine MRI is a sensitive, safe, and noninvasive modality for visualizing upper airway obstruction in children with persistent OSA after T&A. Accurate identification of obstruction can assist in surgical planning in children who fail PAP therapy. •Imaging the site of obstruction is important for managing persistent pediatric OSA.•We have developed a novel dexmedetomidine-based cine MRI protocol.•This protocol may improve outcomes in persistent OSA after adenotonsillectomy.