Emerging Treatments in Episodic Migraine

• Published in: Current pain and headache reports 2018-09, Vol.22 (9), p.61-61, Article 61
• Main Authors: Grimsrud, Kate W., Halker Singh, Rashmi B.
• Format: Article
• Language: English
• Subjects: Episodic Migraine (S Nahas; Internal Medicine; Medicine; Medicine & Public Health; Pain Medicine; Section Editor; Topical Collection on Episodic Migraine
• ISSN: 1531-3433; 1534-3081
• DOI: 10.1007/s11916-018-0716-2

Purpose of Review The purpose of this review is to evaluate and describe recent and emerging treatment options for episodic migraine. Recent Findings Recent advances have been made in better understanding the pathophysiology of migraine, which has led to further investigation of potential new pharmacologic and non-pharmacologic treatment options. Summary A number of new medications are emerging for the acute and preventive treatment of migraine, including CGRP monoclonal antibodies, CGRP receptor antagonists, serotonin 5-HT 1F agonists, and PACAP receptor monoclonal antibodies. Additionally, newer studies on existing non-invasive neuromodulation devices including transcranial magnetic stimulation, supraorbital transcutaneous nerve stimulation, and transcutaneous vagus nerve stimulation have recently received FDA approval for use in migraine. Neuromodulation devices including percutaneous mastoid electrical stimulation, non-painful remote electrical stimulation, and caloric vestibular stimulation are undergoing further investigation and have shown promising results thus far. These new developments are expected to contribute to better treatment and decreased disability in migraine.