Optical Performance of the Cornea One Year Following Keratoconus Treatment with Corneal Collagen Cross-Linking

The purpose of the study is to assess changes in optical performance of the cornea in patients with keratoconus following treatment with corneal collagen crosslinking (CXL). One hundred and eleven eyes of 111 consecutive keratoconus patients with 12-month follow-up after CXL were included. The chang...

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Bibliographic Details
Published in:Current eye research 2018-12, Vol.43 (12), p.1415-1421
Main Authors: Uysal, Betul Seher, Sarac, Ozge, Yaman, Derya, Akcay, Emine, Cagil, Nurullah
Format: Article
Language:English
Subjects:
Adolescent
Adult
Child
Collagen - therapeutic use
Cornea - pathology
Corneal collagen crosslinking
Corneal Topography
Cross-Linking Reagents - therapeutic use
Female
Follow-Up Studies
higher order aberrations
Humans
keratoconus
Keratoconus - diagnosis
Keratoconus - drug therapy
Male
modulation transfer function
Photochemotherapy - methods
Photosensitizing Agents - therapeutic use
point spread function
Refraction, Ocular - physiology
Retrospective Studies
Riboflavin - therapeutic use
Time Factors
Visual Acuity
Young Adult
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Summary:The purpose of the study is to assess changes in optical performance of the cornea in patients with keratoconus following treatment with corneal collagen crosslinking (CXL). One hundred and eleven eyes of 111 consecutive keratoconus patients with 12-month follow-up after CXL were included. The changes in the visual acuity, manifest refractive errors, and corneal topographic parameters were evaluated. Sirius dual-scanning corneal tomography was used to determine the effectiveness of CXL on each patient's total corneal optical quality; preoperative and 12-month postoperative measurements were analyzed over a 4-mm stimulated pupil and were compared with regards to higher order corneal aberrations (total amount of higher order aberrations [HOAs], vertical coma, horizontal coma, vertical trefoil, oblique trefoil, and spherical aberration), vertical and horizontal modulation transfer function (MTF), and Strehl ratio of point spread function (PSF). At 12 months, there was a significant improvement in mean uncorrected visual acuity (UCVA) (P 
ISSN:0271-3683
1460-2202
DOI:10.1080/02713683.2018.1501802