Multi-drug delivery system based on lipid membrane mimetic coated nano-hydroxyapatite formulations

[Display omitted] Local delivery systems from an osteoconductive biomaterial are suggested as a promising strategy to avoid simultaneously peri-implant traumas and to induce tissue regeneration. In this work, it is detailed the design and construction of a multi-drug delivery formulation based on li...

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Bibliographic Details
Published in:International journal of pharmaceutics 2018-09, Vol.548 (1), p.559-570
Main Authors: Placente, Damián, Benedini, Luciano A., Baldini, Mónica, Laiuppa, Juan A., Santillán, Graciela E., Messina, Paula V.
Format: Article
Language:English
Subjects:
Bone-tissue
Ciprofloxacin
Hydroxyapatite
Ibuprofen
Multi-drug delivery system
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Summary:[Display omitted] Local delivery systems from an osteoconductive biomaterial are suggested as a promising strategy to avoid simultaneously peri-implant traumas and to induce tissue regeneration. In this work, it is detailed the design and construction of a multi-drug delivery formulation based on lipid membrane mimetic coated nano-hydroxyapatite, LMm/nano-HA, as a bone-specific drug delivery approach. The optimal LMm/nano-HA formulation was selected after analysing the lipid/nano-HA interaction by dynamic light scattering (DLS), ζ-potential, transmission electron microscopy (TEM), polarized optical microscopy (POM), differential scanning calorimetry (DSC) and UV–vis spectroscopy. After the initial screening, Ciprofloxacin and Ibuprofen simultaneous -load and -release efficiency from selected LMm/nano-HA was assessed. pH-responsive kinetic profiles of local drug distribution were characterized and compared with currently applied systemic doses. Finally, the systems’ biocompatibility and drug released activity were positively validated. The obtained results demonstrated that LMm/nano-HA formulations can represent a valuable multi-modal platform in bone tissue therapies.
ISSN:0378-5173
1873-3476
DOI:10.1016/j.ijpharm.2018.07.036