Use of sulfadimethoxine in intensive calf farming: evaluation of transfer to stable manure and soil

After prophylactic treatment of 50 calves with 62 mg kg −1 day −1 of sulfadimethoxine (SDM) for five days, the levels of the drug over time were followed in feces, bedding and stable manure, and then in the soil of a manured field and surrounding drainage courses. Analysis were done by HPLC after ap...

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Bibliographic Details
Published in:Chemosphere (Oxford) 2007-06, Vol.68 (4), p.671-676
Main Authors: De Liguoro, Marco, Poltronieri, Carlo, Capolongo, Francesca, Montesissa, Clara
Format: Article
Language:English
Subjects:
agricultural runoff
Agriculture - methods
Animal, plant and microbial ecology
Animals
Anti-Infective Agents - pharmacokinetics
Anti-Infective Agents - toxicity
Applied ecology
Applied sciences
Biological and medical sciences
calves
Cattle
cattle manure
cattle production
chemoprevention
contamination
Daphnia
Daphnia - drug effects
Daphnia - physiology
Daphnia magna
Degradation
drug residues
Ecotoxicology, biological effects of pollution
Environment
environmental fate
Exact sciences and technology
feces
Feces - chemistry
Fundamental and applied biological sciences. Psychology
General aspects
half life
intensive livestock farming
litter (bedding)
losses from soil
Manure - analysis
manure spreading
Motor Activity - drug effects
oral administration
Pollution
Risk Assessment
Soil - analysis
soil pollution
soil treatment
sulfadimethoxine
Sulfadimethoxine - pharmacokinetics
Sulfadimethoxine - toxicity
Sulfonamide
toxicity testing
Veterinary
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Summary:After prophylactic treatment of 50 calves with 62 mg kg −1 day −1 of sulfadimethoxine (SDM) for five days, the levels of the drug over time were followed in feces, bedding and stable manure, and then in the soil of a manured field and surrounding drainage courses. Analysis were done by HPLC after applying to the different matrices a quick and simple extraction procedure. The half-life of the drug in bedding was very short (24 h). In stable manure the degradation rate of the drug slowed down and the calculated half-life was 64 days, with 390 μg kg −1 of SDM still detectable after three months maturation. However, in a five months matured stable manure obtained from other groups of calves subjected to the same prophylactic treatment, levels of SDM were 1000.
ISSN:0045-6535
1879-1298
DOI:10.1016/j.chemosphere.2007.02.009