The outcome of pregnancy following topiramate treatment: A study on 52 pregnancies

In spite of a substantial increase in the use of topiramate at child bearing age, very little is known regarding its use in pregnancy. We describe the outcome of 52 pregnancies with 41 liveborn infants from which it seems that topiramate reduces birth weight without decreasing gestational age at del...

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Bibliographic Details
Published in:Reproductive toxicology (Elmsford, N.Y.) N.Y.), 2008-04, Vol.25 (3), p.388-389
Main Authors: Ornoy, Asher, Zvi, Naama, Arnon, Judy, Wajnberg, Rebecka, Shechtman, Svetlana, Diav-Citrin, Orna
Format: Article
Language:English
Subjects:
Abnormalities, Drug-Induced
Abortion, Spontaneous - chemically induced
Anticonvulsants - toxicity
Biological and medical sciences
Birth Weight - drug effects
Congenital anomalies
Embryology: invertebrates and vertebrates. Teratology
Female
Fructose - analogs & derivatives
Fructose - toxicity
Fundamental and applied biological sciences. Psychology
Humans
Infant, Newborn
Medical sciences
Pregnancy
Spontaneous abortions
Teratology. Teratogens
Topiramate
Toxicology
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Summary:In spite of a substantial increase in the use of topiramate at child bearing age, very little is known regarding its use in pregnancy. We describe the outcome of 52 pregnancies with 41 liveborn infants from which it seems that topiramate reduces birth weight without decreasing gestational age at delivery, but does not seem to increase the risk for structural defects. There was an increased rate of spontaneous abortions not related to the drug effects.
ISSN:0890-6238
1873-1708
DOI:10.1016/j.reprotox.2008.03.001